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题名: Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii
作者: Ke, Lei-Yu1, 2, 3, 4; Zhang, Yu1, 2; Xia, Meng-Yuan1, 2, 3; Zhuo, Jing-Xian1, 2; Wang, Yue-Hu1, 2, 3; Long, Chun-Lin5
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4 -> 3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane diterpenoids through a Diels-Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1-3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three diterpenoids (1-3) were evaluated for HO their growth-inhibitory activities against several human cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 mu M).
出版日期: 2018-02-01
卷号: 81, 期号:2, 页码:418-422
DOI标识: 10.1021/acs.jnatprod.7b00909
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/60536
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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