Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii
Ke, Lei-Yu1,2,3,4; Zhang, Yu1,2; Xia, Meng-Yuan1,2,3; Zhuo, Jing-Xian1,2; Wang, Yue-Hu1,2,3; Long, Chun-Lin5
2018-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号81页码:418-422
摘要A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4 -> 3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane diterpenoids through a Diels-Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1-3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three diterpenoids (1-3) were evaluated for HO their growth-inhibitory activities against several human cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 mu M).
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60536
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,et al. Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):418-422.
APA Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,Zhuo, Jing-Xian,Wang, Yue-Hu,&Long, Chun-Lin.(2018).Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii.JOURNAL OF NATURAL PRODUCTS,81(2),418-422.
MLA Ke, Lei-Yu,et al."Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii".JOURNAL OF NATURAL PRODUCTS 81.2(2018):418-422.
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