Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii

doi:10.1021/acs.jnatprod.7b00909

	Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii
	Ke, Lei-Yu 1,2,3,4; Zhang, Yu1,2 ; Xia, Meng-Yuan 1,2,3; Zhuo, Jing-Xian 1,2; Wang, Yue-Hu1,2,3 ; Long, Chun-Lin 5
	2018-02-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:2 页码:418-422
摘要	A new modified abietane diterpenoid, (3S,4S,5R,10S)-18(4 -> 3)-abeo-3,4,12,18-tetrahydroxy-8,11,13-abietatrien-7-one (1), and two novel dimers, selaginedorffones A (2) and B (3), featuring a new cyclohexene moiety that was biogenetically constructed from two modified abietane diterpenoids through a Diels-Alder reaction were obtained from a methanolic extract of Selaginella moellendorffii, a traditional Chinese herb. The structures of 1-3 were identified by a combination of NMR spectroscopic analysis and ECD calculations. In the present study, diterpenoids were identified from S. moellendorffii for the first time, which supports the presence of diterpene synthases in this plant. These three diterpenoids (1-3) were evaluated for HO their growth-inhibitory activities against several human cancer cell lines. Of these substances, selaginedorffone B (3) showed cytotoxicity against the MCF-7 human-breast-cancer-cell line (IC50 9.0 mu M).
DOI	10.1021/acs.jnatprod.7b00909
语种	英语
WOS记录号	WOS:000426618300028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60536
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,et al. Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(2):418-422.
APA	Ke, Lei-Yu,Zhang, Yu,Xia, Meng-Yuan,Zhuo, Jing-Xian,Wang, Yue-Hu,&Long, Chun-Lin.(2018).Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii.JOURNAL OF NATURAL PRODUCTS,81(2),418-422.
MLA	Ke, Lei-Yu,et al."Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii".JOURNAL OF NATURAL PRODUCTS 81.2(2018):418-422.