A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336

doi:10.1080/14786419.2017.1338285

	A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336
	Yu, Fei-Xue 1,2,3; Chen, Yao 3; Yang, Yin-He 4; Li, Guo-Hong 1,2; Zhao, Pei-Ji 1,2,4
	2018
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	32 期号:6 页码:689-694
摘要	A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 mu g/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.627.1 nM against cell lines HeLa, SGC-7901 and A549.
关键词	Chaetomium Sp M336 Chemical Constituents Structure Identification 6-formamide-chetomin Cytotoxicity Antibacterial Activities
DOI	10.1080/14786419.2017.1338285
语种	英语
WOS记录号	WOS:000426942800010
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60529
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Minist Educ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming, Yunnan, Peoples R China 2.Yunnan Univ, Minist Educ, Key Lab Microbial Resources, Kunming, Yunnan, Peoples R China 3.Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,et al. A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336[J]. NATURAL PRODUCT RESEARCH,2018,32(6):689-694.
APA	Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,Li, Guo-Hong,&Zhao, Pei-Ji.(2018).A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336.NATURAL PRODUCT RESEARCH,32(6),689-694.
MLA	Yu, Fei-Xue,et al."A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336".NATURAL PRODUCT RESEARCH 32.6(2018):689-694.