A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336
Yu, Fei-Xue1,2,3; Chen, Yao3; Yang, Yin-He4; Li, Guo-Hong1,2; Zhao, Pei-Ji1,2,4
2018
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
卷号32页码:689-694
摘要A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 mu g/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.627.1 nM against cell lines HeLa, SGC-7901 and A549.
关键词Chaetomium Sp M336 Chemical Constituents Structure Identification 6-formamide-chetomin Cytotoxicity Antibacterial Activities
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60529
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Minist Educ, State Key Lab Conservat & Utilizat Bioresources Y, Kunming, Yunnan, Peoples R China
2.Yunnan Univ, Minist Educ, Key Lab Microbial Resources, Kunming, Yunnan, Peoples R China
3.Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
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Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,et al. A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336[J]. NATURAL PRODUCT RESEARCH,2018,32(6):689-694.
APA Yu, Fei-Xue,Chen, Yao,Yang, Yin-He,Li, Guo-Hong,&Zhao, Pei-Ji.(2018).A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336.NATURAL PRODUCT RESEARCH,32(6),689-694.
MLA Yu, Fei-Xue,et al."A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp M336".NATURAL PRODUCT RESEARCH 32.6(2018):689-694.
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