Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum

doi:10.1021/acs.orglett.8b00366

	Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum
	Bian, Guangkai 1,2,5; Hou, Anwei 1,2,5; Yuan, Yujie 1,2; Hu, Ben 1,2; Cheng, Shu 1,2; Ye, Ziling 2,3; Di, Yingtong4,5 ; Deng, Zixin 1,2,5; Liu, Tiangang 1,2,5
	2018-03-16
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	20 期号:6 页码:1626-1629
摘要	The potential power of sesquiterpene synthase FgJ03939 from Fusarium graminearum was fully exploited in a farnesyl diphosphate-overexpressing Saccharomyces cerevisiae chassis to produce the novel sesquiterpenes fusariumdiene (1), epi-fusagramineol (2), and fusagramineol (3) with 5/7 bicyclic and 5/6/3 tricyclic ring systems, respectively, as well as five known sesquiterpenes (4-8). The structure of the unusual skeletons was characterized, and an absolute configuration was proposed. A mechanism for the biosynthesis of 1-8 was also proposed.
DOI	10.1021/acs.orglett.8b00366
语种	英语
WOS记录号	WOS:000428003600036
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60520
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China 2.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China 3.J1 Biotech Co Ltd, Wuhan 430075, Hubei, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Wuhan Inst Biotechnol, Hubei Engn Lab Synthet Microbiol, Wuhan 430075, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Bian, Guangkai,Hou, Anwei,Yuan, Yujie,et al. Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum[J]. ORGANIC LETTERS,2018,20(6):1626-1629.
APA	Bian, Guangkai.,Hou, Anwei.,Yuan, Yujie.,Hu, Ben.,Cheng, Shu.,...&Liu, Tiangang.(2018).Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum.ORGANIC LETTERS,20(6),1626-1629.
MLA	Bian, Guangkai,et al."Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum".ORGANIC LETTERS 20.6(2018):1626-1629.

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