Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)
Ma, Xiaofang1; Zhang, Yingying1; Liu, Bin1; Yang, Jiahui1,2; Hu, Kaifeng1
2018-04-01
发表期刊BIOMOLECULAR NMR ASSIGNMENTS
ISSN1874-2718
卷号12期号:1页码:145-148
摘要

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expresses at high level in many cancers and has been suggested as a potential therapeutic target. It was reported that the Kringle (KNG) domain of ROR1 extracellular region is involved in ROR1/ROR2 heterooligomerization. Monoantibodies that target KNG domain of ROR1 could induce apoptosis of chronic lymphocytic leukemia cells. Here we present the backbone and side chain assignments of KNG domain of ROR1, which lays a foundation for its further structural and function research.

关键词Ror1 Kringle Nmr
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60514
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Chengdu Univ TCM, Sch Basic Med, 1166 Liutai Ave, Chengdu 611137, Sichuan, Peoples R China
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GB/T 7714
Ma, Xiaofang,Zhang, Yingying,Liu, Bin,et al. Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)[J]. BIOMOLECULAR NMR ASSIGNMENTS,2018,12(1):145-148.
APA Ma, Xiaofang,Zhang, Yingying,Liu, Bin,Yang, Jiahui,&Hu, Kaifeng.(2018).Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).BIOMOLECULAR NMR ASSIGNMENTS,12(1),145-148.
MLA Ma, Xiaofang,et al."Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)".BIOMOLECULAR NMR ASSIGNMENTS 12.1(2018):145-148.
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