Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors
Shang, Feineng1,2; Gao, Na1,3; Yin, Ronghua1; Lin, Lisha1; Xiao, Chuang1; Zhou, Lutan1; Li, Zi1; Purcell, Steven W.4; Wu, Mingyi1; Zhao, Jinhua1
2018-03-25
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN0223-5234
Volume148Pages:423-435
Abstract

Selective inhibition of the endogenous coagulation pathway is a promising strategy for developing new anticoagulants. Fucosylated glycosaminoglycan (FG), a structurally complex glycosaminoglycan, has distinct anticoagulant properties, especially the strong intrinsic factor Xase inhibitory activity that is recognized as a new target with potential physiological and therapeutic applications. Detailed knowledge of FG structures is necessary for developing a clinically effective intrinsic FXase inhibitor. However, challenges remain to elucidate FG structures as a basis for pharmaceutical development. Herein, using the highly selective beta-elimination method, oligosaccharides with regular structures were prepared from the depolymerization products. Analysis of oligosaccharides further confirmed the precise structural sequence of the FG. Furthermore, biological activity assay suggested that these pure homogeneous oligosaccharides, particularly an octasaccharide, exhibit strong inhibition of the intrinsic coagulation pathway by inhibiting human intrinsic factor Xase. Our finding is significant for discovery of a new class of anticoagulant agents as intrinsic factor Xase inhibitors. (C) 2018 Elsevier Masson SAS. All rights reserved.

KeywordGlycosaminoglycan Oligosaccharide Anticoagulant Intrinsic Factor Xase
DOI10.1016/j.ejmech.2018.02.047
Language英语
WOS IDWOS:000428824700034
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60504
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Dali Univ, Sch Chem & Pharm, Dali 671003, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
4.Southern Cross Univ, Natl Marine Sci Ctr, Coffs Harbour, NSW 2480, Australia
Recommended Citation
GB/T 7714
Shang, Feineng,Gao, Na,Yin, Ronghua,et al. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,148:423-435.
APA Shang, Feineng.,Gao, Na.,Yin, Ronghua.,Lin, Lisha.,Xiao, Chuang.,...&Zhao, Jinhua.(2018).Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,148,423-435.
MLA Shang, Feineng,et al."Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 148(2018):423-435.
Files in This Item: Download All
File Name/Size DocType Version Access License
论文-5.pdf(3117KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shang, Feineng]'s Articles
[Gao, Na]'s Articles
[Yin, Ronghua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shang, Feineng]'s Articles
[Gao, Na]'s Articles
[Yin, Ronghua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shang, Feineng]'s Articles
[Gao, Na]'s Articles
[Yin, Ronghua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 论文-5.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.