Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera
Chen, He-Ping1; Zhao, Zhen-Zhu1,2; Li, Zheng-Hui1; Huang, Ying1; Zhang, Shuai-Bing1; Tang, Yang1,2; Yao, Jian-Neng1,2; Chen, Lin1; Isaka, Masahiko3; Feng, Tao1; Liu, Ji-Kai1
2018-03-28
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号66期号:12页码:3146-3154
摘要This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A-L, 1-12, from the fruiting bodies of the Poland-collected edible mushroom Macrolepiota procera. The structures and the absolute configurations of the new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F, 1-6, are distinguished by the presence of a rare "1-en-1,11-epoxy" moiety which has not been previously described in the lanostane class. Biologically, lepiotaprocerins A-F, 1-6, displayed more significant inhibitions of nitric oxide (NO) production than the positive control L-N-G-monomethyl arginine (L-NMMA) (IC50 47.1 mu M), and lepiotaprocerins G-L, 7-12, showed various cytotoxicity potencies against a panel of human cancer cell lines. Compound 9 also displayed antitubercular activity against Mycobacterium tuberculosis H37Ra with a minimal inhibitory concentration (MIC) 50 mu g/mL.
关键词Mushroom Macrolepiota Procera Lanostane Triterpenoid Anti-inflammatory Activity Cytotoxicity
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60503
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.South Cent Univ Nationalities, Coll Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Natl Ctr Genet Engn & Biotechnol BIOTEC, 113 Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathumthani, Thailand
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Chen, He-Ping,Zhao, Zhen-Zhu,Li, Zheng-Hui,et al. Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(12):3146-3154.
APA Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,Huang, Ying.,Zhang, Shuai-Bing.,...&Liu, Ji-Kai.(2018).Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(12),3146-3154.
MLA Chen, He-Ping,et al."Anti-Proliferative and Anti-Inflammatory Lanostane Triterpenoids from the Polish Edible Mushroom Macrolepiota procera".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.12(2018):3146-3154.
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