| Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells | |
Wei, Xin1,4; Dai, Zhi2,4; Yang, Jing1 ; Khan, Afsar3; Yu, Hao-Fei1,4; Zhao, Yun-Li1; Wang, Yi-Fen1; Liu, Ya-Ping1; Yang, Zi-Feng5; Huang, Wan-Yi5; Wang, Xin-Hua5; Zhao, Xu-Dong2; Luo, Xiao-Dong1,5
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| 2018-05-01 | |
| Source Publication | BIOORGANIC & MEDICINAL CHEMISTRY
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| ISSN | 0968-0896 |
| Volume | 26Issue:8Pages:1776-1783 |
| Abstract | Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-alpha), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. (C) 2018 Elsevier Ltd. All rights reserved. |
| Keyword | Alstoniasidines a And b Sugar Bridged Bisindole Glioma Stem Cells Alstonia Scholaris |
| DOI | 10.1016/j.bmc.2018.02.024 |
| Language | 英语 |
| WOS ID | WOS:000429533300037 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/60494 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Xin,Dai, Zhi,Yang, Jing,et al. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(8):1776-1783. |
| APA | Wei, Xin.,Dai, Zhi.,Yang, Jing.,Khan, Afsar.,Yu, Hao-Fei.,...&Luo, Xiao-Dong.(2018).Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.BIOORGANIC & MEDICINAL CHEMISTRY,26(8),1776-1783. |
| MLA | Wei, Xin,et al."Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells".BIOORGANIC & MEDICINAL CHEMISTRY 26.8(2018):1776-1783. |
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