Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
Wei, Xin1,4; Dai, Zhi2,4; Yang, Jing1; Khan, Afsar3; Yu, Hao-Fei1,4; Zhao, Yun-Li1; Wang, Yi-Fen1; Liu, Ya-Ping1; Yang, Zi-Feng5; Huang, Wan-Yi5; Wang, Xin-Hua5; Zhao, Xu-Dong2; Luo, Xiao-Dong1,5
AbstractUnlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-alpha), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordAlstoniasidines a And b Sugar Bridged Bisindole Glioma Stem Cells Alstonia Scholaris
WOS IDWOS:000429533300037
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China
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Wei, Xin,Dai, Zhi,Yang, Jing,et al. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(8):1776-1783.
APA Wei, Xin.,Dai, Zhi.,Yang, Jing.,Khan, Afsar.,Yu, Hao-Fei.,...&Luo, Xiao-Dong.(2018).Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.BIOORGANIC & MEDICINAL CHEMISTRY,26(8),1776-1783.
MLA Wei, Xin,et al."Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells".BIOORGANIC & MEDICINAL CHEMISTRY 26.8(2018):1776-1783.
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