Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells

doi:10.1016/j.bmc.2018.02.024

	Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells
	Wei, Xin 1,4; Dai, Zhi 2,4; Yang, Jing1 ; Khan, Afsar 3; Yu, Hao-Fei 1,4; Zhao, Yun-Li 1; Wang, Yi-Fen1 ; Liu, Ya-Ping 1; Yang, Zi-Feng 5; Huang, Wan-Yi 5; Wang, Xin-Hua 5; Zhao, Xu-Dong 2; Luo, Xiao-Dong1,5
	2018-05-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY
ISSN	0968-0896
卷号	26 期号:8 页码:1776-1783
摘要	Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-alpha), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. (C) 2018 Elsevier Ltd. All rights reserved.
关键词	Alstoniasidines a And b Sugar Bridged Bisindole Glioma Stem Cells Alstonia Scholaris
DOI	10.1016/j.bmc.2018.02.024
语种	英语
WOS记录号	WOS:000429533300037
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60494
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Bioact Peptides Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.COMSATS Inst Informat Technol, Dept Chem, Abbottabad 22060, Pakistan 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Guangzhou Med Univ, Guangzhou 511436, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wei, Xin,Dai, Zhi,Yang, Jing,et al. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(8):1776-1783.
APA	Wei, Xin.,Dai, Zhi.,Yang, Jing.,Khan, Afsar.,Yu, Hao-Fei.,...&Luo, Xiao-Dong.(2018).Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.BIOORGANIC & MEDICINAL CHEMISTRY,26(8),1776-1783.
MLA	Wei, Xin,et al."Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells".BIOORGANIC & MEDICINAL CHEMISTRY 26.8(2018):1776-1783.