Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis
Pu, De-Bing1,3,4; Wang, Ting2; Zhang, Xing-Jie1; Gao, Jun-Bo3,4; Zhang, Rui-Han1; Li, Xiao-Nian3; Wang, Yong-Mei3,4; Li, Xiao-Li1; Wang, He-Yao2; Xiao, Wei-Lie1,3
2018
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume8Issue:12Pages:6425-6435
AbstractInvestigation of the leaves and stems of Premna szemaoensis resulted in the isolation of twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known abietane diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 -> 16)-abeo-abietane (7, 10-12, 14 and 15) and 17(15 -> 16), 18(4 -> 3)-diabeo-abietane (1-6, 13 and 16). The structures of the new compounds were established mainly by analyzing NMR and HRESIMS data. The absolute configurations of 1, 3 and 10 were confirmed by single crystal X-ray diffraction analysis. In bioactivity assays, compounds 11, 12, 14 and 15 were active against two human colon cancer cell lines (HCT-116 and HT-29) with IC50 values ranging from 8.8 to 34.3 mu M, and compounds 10, 13 and 14 exhibited effective free radical scavenging activity with IC50 values ranging from 35.6 to 41.5 mu M by DPPH experiment.
DOI10.1039/c7ra13309j
Language英语
WOS IDWOS:000425034000030
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60455
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, State Key Lab Conservat & Utilizat Bioresources Y, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Pu, De-Bing,Wang, Ting,Zhang, Xing-Jie,et al. Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis[J]. RSC ADVANCES,2018,8(12):6425-6435.
APA Pu, De-Bing.,Wang, Ting.,Zhang, Xing-Jie.,Gao, Jun-Bo.,Zhang, Rui-Han.,...&Xiao, Wei-Lie.(2018).Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis.RSC ADVANCES,8(12),6425-6435.
MLA Pu, De-Bing,et al."Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis".RSC ADVANCES 8.12(2018):6425-6435.
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