Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis

doi:10.1039/c7ra13309j

	Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis
	Pu, De-Bing1,3,4 ; Wang, Ting 2; Zhang, Xing-Jie 1; Gao, Jun-Bo 3,4; Zhang, Rui-Han 1; Li, Xiao-Nian 3; Wang, Yong-Mei 3,4; Li, Xiao-Li 1; Wang, He-Yao 2; Xiao, Wei-Lie 1,3
	2018
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	8 期号:12 页码:6425-6435
摘要	Investigation of the leaves and stems of Premna szemaoensis resulted in the isolation of twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known abietane diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 -> 16)-abeo-abietane (7, 10-12, 14 and 15) and 17(15 -> 16), 18(4 -> 3)-diabeo-abietane (1-6, 13 and 16). The structures of the new compounds were established mainly by analyzing NMR and HRESIMS data. The absolute configurations of 1, 3 and 10 were confirmed by single crystal X-ray diffraction analysis. In bioactivity assays, compounds 11, 12, 14 and 15 were active against two human colon cancer cell lines (HCT-116 and HT-29) with IC50 values ranging from 8.8 to 34.3 mu M, and compounds 10, 13 and 14 exhibited effective free radical scavenging activity with IC50 values ranging from 35.6 to 41.5 mu M by DPPH experiment.
DOI	10.1039/c7ra13309j
语种	英语
WOS记录号	WOS:000425034000030
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60455
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, State Key Lab Conservat & Utilizat Bioresources Y, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Pu, De-Bing,Wang, Ting,Zhang, Xing-Jie,et al. Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis[J]. RSC ADVANCES,2018,8(12):6425-6435.
APA	Pu, De-Bing.,Wang, Ting.,Zhang, Xing-Jie.,Gao, Jun-Bo.,Zhang, Rui-Han.,...&Xiao, Wei-Lie.(2018).Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis.RSC ADVANCES,8(12),6425-6435.
MLA	Pu, De-Bing,et al."Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis".RSC ADVANCES 8.12(2018):6425-6435.