| Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis | |
Nian, Yin1 ; Lu, Ni-Hong2; Liu, Xiao-Ling1; Li, Da-Shan1; Zhou, Lin1; Qiu, Ming-Hua1
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| 2018 | |
| Source Publication | RSC ADVANCES
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| ISSN | 2046-2069 |
| Volume | 8Issue:14Pages:7832-7838 |
| Abstract | Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro [4.4] nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 mu M, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 mu M. |
| DOI | 10.1039/c8ra00291f |
| Language | 英语 |
| WOS ID | WOS:000425647000058 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/60450 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Third Peoples Hosp Kunming, Dept Resp Med, Kunming 650041, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,et al. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis[J]. RSC ADVANCES,2018,8(14):7832-7838. |
| APA | Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,Li, Da-Shan,Zhou, Lin,&Qiu, Ming-Hua.(2018).Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.RSC ADVANCES,8(14),7832-7838. |
| MLA | Nian, Yin,et al."Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis".RSC ADVANCES 8.14(2018):7832-7838. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| nian2018.pdf（517KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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