Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
Nian, Yin1; Lu, Ni-Hong2; Liu, Xiao-Ling1; Li, Da-Shan1; Zhou, Lin1; Qiu, Ming-Hua1
2018
发表期刊RSC ADVANCES
ISSN2046-2069
卷号8期号:14页码:7832-7838
摘要Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro [4.4] nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 mu M, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 mu M.
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60450
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Third Peoples Hosp Kunming, Dept Resp Med, Kunming 650041, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,et al. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis[J]. RSC ADVANCES,2018,8(14):7832-7838.
APA Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,Li, Da-Shan,Zhou, Lin,&Qiu, Ming-Hua.(2018).Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.RSC ADVANCES,8(14),7832-7838.
MLA Nian, Yin,et al."Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis".RSC ADVANCES 8.14(2018):7832-7838.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
nian2018.pdf(517KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Nian, Yin]的文章
[Lu, Ni-Hong]的文章
[Liu, Xiao-Ling]的文章
百度学术
百度学术中相似的文章
[Nian, Yin]的文章
[Lu, Ni-Hong]的文章
[Liu, Xiao-Ling]的文章
必应学术
必应学术中相似的文章
[Nian, Yin]的文章
[Lu, Ni-Hong]的文章
[Liu, Xiao-Ling]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。