Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

doi:10.1039/c8ra00291f

	Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
	Nian, Yin1 ; Lu, Ni-Hong 2; Liu, Xiao-Ling 1; Li, Da-Shan 1; Zhou, Lin 1; Qiu, Ming-Hua1
	2018
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	8 期号:14 页码:7832-7838
摘要	Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro [4.4] nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 mu M, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 mu M.
DOI	10.1039/c8ra00291f
语种	英语
WOS记录号	WOS:000425647000058
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/60450
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Third Peoples Hosp Kunming, Dept Resp Med, Kunming 650041, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,et al. Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis[J]. RSC ADVANCES,2018,8(14):7832-7838.
APA	Nian, Yin,Lu, Ni-Hong,Liu, Xiao-Ling,Li, Da-Shan,Zhou, Lin,&Qiu, Ming-Hua.(2018).Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.RSC ADVANCES,8(14),7832-7838.
MLA	Nian, Yin,et al."Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis".RSC ADVANCES 8.14(2018):7832-7838.

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