| Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae | |
| Chen, Lin1; Li, Zheng-Hui1; Yao, Jian-Neng2,3; Peng, Yue-Ling1; Huang, Rong1; Feng, Tao1; Liu, Ji-Kai1 | |
| 2017-10-01 | |
| Source Publication | FITOTERAPIA
 |
| ISSN | 0367-326X |
| Volume | 122Pages:107-114 |
| Abstract | Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins G-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration. The absolute configurations of lt) and 11 were rationalized by the calculation of H-1 NMR chemical shifts. Caputmedusins A-C (1-3) showed moderate inhibitory activity against a-glucosidase with the IC50 values of 39.2, 36.2 and 40.8 mu M, respectively. |
| Keyword | Hericium Caput-medusae Isoindolinone-containing Meroterpenoid Alpha-glucosidase Inhibition |
| DOI | 10.1016/j.fitote.2017.08.017 |
| Language | 英语 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/60358 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Lin,Li, Zheng-Hui,Yao, Jian-Neng,et al. Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae[J]. FITOTERAPIA,2017,122:107-114. |
| APA | Chen, Lin.,Li, Zheng-Hui.,Yao, Jian-Neng.,Peng, Yue-Ling.,Huang, Rong.,...&Liu, Ji-Kai.(2017).Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae.FITOTERAPIA,122,107-114. |
| MLA | Chen, Lin,et al."Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae".FITOTERAPIA 122(2017):107-114. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| chen2017 (2).pdf（475KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment