Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae
Chen, Lin1; Li, Zheng-Hui1; Yao, Jian-Neng2,3; Peng, Yue-Ling1; Huang, Rong1; Feng, Tao1; Liu, Ji-Kai1
2017-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号122页码:107-114
摘要Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins G-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration. The absolute configurations of lt) and 11 were rationalized by the calculation of H-1 NMR chemical shifts. Caputmedusins A-C (1-3) showed moderate inhibitory activity against a-glucosidase with the IC50 values of 39.2, 36.2 and 40.8 mu M, respectively.
关键词Hericium Caput-medusae Isoindolinone-containing Meroterpenoid Alpha-glucosidase Inhibition
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60358
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Chen, Lin,Li, Zheng-Hui,Yao, Jian-Neng,et al. Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae[J]. FITOTERAPIA,2017,122:107-114.
APA Chen, Lin.,Li, Zheng-Hui.,Yao, Jian-Neng.,Peng, Yue-Ling.,Huang, Rong.,...&Liu, Ji-Kai.(2017).Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae.FITOTERAPIA,122,107-114.
MLA Chen, Lin,et al."Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae".FITOTERAPIA 122(2017):107-114.
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