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KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Fine tuning by human CD1e of lipid-specific immune responses
作者: Facciotti, Federica1; Cavallari, Marco1; Angenieux, Catherine2, 3; Garcia-Alles, Luis F.4; Signorino-Gelo, Francois2, 3; Angman, Lena1; Gilleron, Martine4; Prandi, Jacques4; Puzo, Germain4; Panza, Luigi5; null(夏成峰)6; Wang, Peng George7; Dellabona, Paolo8; Casorati, Giulia8; Porcelli, Steven A.9; de la Salle, Henri2, 3; Mori, Lucia1, 10; De Libero, Gennaro1
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
关键词: CD1 restriction ; lipid transfer proteins ; natural killer T cells
英文摘要: CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.
出版日期: 2011-08-23
卷号: 108, 期号:34, 页码:14228-14233
DOI标识: 10.1073/pnas.1108809108
语种: 英语
收录类别: SCI
学科分类: Science & Technology - Other Topics
ISSN号: 0027-8424
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5549
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland
2.Univ Strasbourg, INSERM, UMR S725, F-67065 Strasbourg, France
3.Etab Francais Sang Alsace, F-67065 Strasbourg, France
4.CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
5.Univ Piemonte Orientale, Dept Chem Food Pharmaceut & Pharmacol, I-28100 Novara, Italy
6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
7.Ohio State Univ, Dept Biochem & Chem, Columbus, OH 43210 USA
8.Ist Sci San Raffaele, Expt Immunol Unit, Div Immunol Transplantat & Infect Dis, Dipartimento Biotecnol DIBIT, I-20132 Milan, Italy
9.Albert Einstein Coll Med, Bronx, NY 10461 USA
10.Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore

Recommended Citation:
Facciotti, F; Cavallari, M; Angenieux, C; Garcia-Alles, LF; Signorino-Gelo, F; Angman, L; Gilleron, M; Prandi, J; Puzo, G; Panza, L; Xia, CF; Wang, PG; Dellabona, P; Casorati, G; Porcelli, SA; de la Salle, H; Mori, L; De Libero, G.Fine tuning by human CD1e of lipid-specific immune responses,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(34):14228-14233
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