Fine tuning by human CD1e of lipid-specific immune responses
Facciotti, Federica1; Cavallari, Marco1; Angenieux, Catherine2,3; Garcia-Alles, Luis F.4; Signorino-Gelo, Francois2,3; Angman, Lena1; Gilleron, Martine4; Prandi, Jacques4; Puzo, Germain4; Panza, Luigi5; Xia, Chengfeng6; Wang, Peng George7; Dellabona, Paolo8; Casorati, Giulia8; Porcelli, Steven A.9; de la Salle, Henri2,3; Mori, Lucia1,10; De Libero, Gennaro1
2011-08-23
发表期刊PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
卷号108期号:34页码:14228-14233
摘要CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.
关键词Cd1 Restriction Lipid Transfer Proteins Natural Killer t Cells
资助信息Swiss National Science Foundation[3100A0 122464/1]; European Union; University Hospital Basel; French National Research Agency[ANR-05-MIIM-006]; Etablissement Francais du Sang-Alsace
学科领域Science & Technology - Other Topics
DOI10.1073/pnas.1108809108
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000294163500072
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5549
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland
2.Univ Strasbourg, INSERM, UMR S725, F-67065 Strasbourg, France
3.Etab Francais Sang Alsace, F-67065 Strasbourg, France
4.CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
5.Univ Piemonte Orientale, Dept Chem Food Pharmaceut & Pharmacol, I-28100 Novara, Italy
6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
7.Ohio State Univ, Dept Biochem & Chem, Columbus, OH 43210 USA
8.Ist Sci San Raffaele, Expt Immunol Unit, Div Immunol Transplantat & Infect Dis, Dipartimento Biotecnol DIBIT, I-20132 Milan, Italy
9.Albert Einstein Coll Med, Bronx, NY 10461 USA
10.Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore
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Facciotti, Federica,Cavallari, Marco,Angenieux, Catherine,et al. Fine tuning by human CD1e of lipid-specific immune responses[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(34):14228-14233.
APA Facciotti, Federica.,Cavallari, Marco.,Angenieux, Catherine.,Garcia-Alles, Luis F..,Signorino-Gelo, Francois.,...&De Libero, Gennaro.(2011).Fine tuning by human CD1e of lipid-specific immune responses.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(34),14228-14233.
MLA Facciotti, Federica,et al."Fine tuning by human CD1e of lipid-specific immune responses".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.34(2011):14228-14233.
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