Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production
Zhou, Xiao-Jiang1,2; Chen, Xiao-Liang1; Li, Xue-Song1,2; Su, Jia1; He, Jiang-Bo1; Wang, Yue-Hu1; Li, Yan1; Cheng, Yong-Xian1
2011
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号21期号:1页码:373-376
摘要Two new dimeric lignans, zanthpodocarpins A (1) and B (2), and five known lignans, eudesmin (3), (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), dimethoxysamin (5), rel-(1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octan-2-one (6), and magnone A (7), were isolated from the barks of Zanthoxylum podocarpum. Their structures were identified by using spectroscopic methods. Compounds 1 and 2 are rare dilignans bearing an unusual alpha,beta-unsaturated ketone group from a natural source. Bioassay showed that compounds 1 and 2 could inhibit nitric oxide (NO) production in LPS stimulated RAW 264.7 cells with IC(50) values of 5.31 mu M and 12.15 mu M, respectively. (c) 2010 Elsevier Ltd. All rights reserved.
关键词Zanthoxylum Podocarpum Rutaceae Dimeric Lignans Zanthpodocarpins a And b Nitric Oxide Production
资助信息'Talent Scholarship of Yunnan Youth' from Yunnan Province[2007PY01-48]; Ministry of Science and Technology of China[2008ZX09401-004, 2009CB522300]
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2010.10.135
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000285544400076
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5529
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China
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Zhou, Xiao-Jiang,Chen, Xiao-Liang,Li, Xue-Song,et al. Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(1):373-376.
APA Zhou, Xiao-Jiang.,Chen, Xiao-Liang.,Li, Xue-Song.,Su, Jia.,He, Jiang-Bo.,...&Cheng, Yong-Xian.(2011).Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(1),373-376.
MLA Zhou, Xiao-Jiang,et al."Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.1(2011):373-376.
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