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题名: Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production
作者: Zhou, Xiao-Jiang1, 2; Chen, Xiao-Liang1; Li, Xue-Song1, 2; Su, Jia1; He, Jiang-Bo1; Wang, Yue-Hu1; null(李艳)1; null(程永现)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Zanthoxylum podocarpum ; Rutaceae ; Dimeric lignans ; Zanthpodocarpins A and B ; Nitric oxide production
英文摘要: Two new dimeric lignans, zanthpodocarpins A (1) and B (2), and five known lignans, eudesmin (3), (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), dimethoxysamin (5), rel-(1R,5R,6S)-6-(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octan-2-one (6), and magnone A (7), were isolated from the barks of Zanthoxylum podocarpum. Their structures were identified by using spectroscopic methods. Compounds 1 and 2 are rare dilignans bearing an unusual alpha,beta-unsaturated ketone group from a natural source. Bioassay showed that compounds 1 and 2 could inhibit nitric oxide (NO) production in LPS stimulated RAW 264.7 cells with IC(50) values of 5.31 mu M and 12.15 mu M, respectively. (c) 2010 Elsevier Ltd. All rights reserved.
出版日期: 2011
卷号: 21, 期号:1, 页码:373-376
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy; Chemistry
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5529
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China

Recommended Citation:
Zhou, XJ; Chen, XL; Li, XS; Su, J; He, JB; Wang, YH; Li, Y; Cheng, YX.Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(1):373-376
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