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题名: Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
作者: null(程永现)1; Zhou, Li-Li2; Yan, Yong-Ming1; Chen, Ke-Xin1; Hou, Fan-Fan2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Brachystemma calycinum ; Caryophyllaceae ; Cyclic peptides ; Cytokines ; Collagen IV ; ROS
英文摘要: Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
出版日期: 2011-12-15
卷号: 21, 期号:24, 页码:7434-7439
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy; Chemistry
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5525
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China

Recommended Citation:
Cheng, YX; Zhou, LL; Yan, YM; Chen, KX; Hou, FF.Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(24):7434-7439
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