| Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum | |
| Cheng, Yong-Xian1; Zhou, Li-Li2; Yan, Yong-Ming1; Chen, Ke-Xin1; Hou, Fan-Fan2 | |
| 通讯作者 | Cheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 2011-12-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 0960-894X |
| 卷号 | 21期号:24页码:7434-7439 |
| 摘要 | Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved. |
| 关键词 | Brachystemma Calycinum Caryophyllaceae Cyclic Peptides Cytokines Collagen Iv Ros |
| 学科领域 | Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmcl.2011.10.004 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297150600039 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5525 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,et al. Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(24):7434-7439. |
| APA | Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,Chen, Ke-Xin,&Hou, Fan-Fan.(2011).Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(24),7434-7439. |
| MLA | Cheng, Yong-Xian,et al."Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.24(2011):7434-7439. |
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