Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum
Cheng, Yong-Xian1; Zhou, Li-Li2; Yan, Yong-Ming1; Chen, Ke-Xin1; Hou, Fan-Fan2
Corresponding AuthorCheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2011-12-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume21Issue:24Pages:7434-7439
AbstractThree new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordBrachystemma Calycinum Caryophyllaceae Cyclic Peptides Cytokines Collagen Iv Ros
Subject AreaPharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2011.10.004
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000297150600039
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5525
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,et al. Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(24):7434-7439.
APA Cheng, Yong-Xian,Zhou, Li-Li,Yan, Yong-Ming,Chen, Ke-Xin,&Hou, Fan-Fan.(2011).Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(24),7434-7439.
MLA Cheng, Yong-Xian,et al."Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.24(2011):7434-7439.
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