Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives

doi:10.1016/j.bmcl.2011.02.087

	Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives
	Bai, Bing 1,3; Li, Xing-Yao 1,3; Li, Yan1 ; Zhu, Hua-Jie 1,2
通讯作者	Li, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China
	2011-04-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	21 期号:8 页码:2302-2304
摘要	Three series of novel beta-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did. (C) 2011 Elsevier Ltd. All rights reserved.
关键词	Beta-amino Alcohol Cytotoxic Activity Structure-activity Relationship Mtt
学科领域	Pharmacology & Pharmacy ; Chemistry
DOI	10.1016/j.bmcl.2011.02.087
收录类别	SCI
语种	英语
WOS记录号	WOS:000289074700025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5523
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China 2.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Coll Life Sci, Baoding 071002, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bai, Bing,Li, Xing-Yao,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(8):2302-2304.
APA	Bai, Bing,Li, Xing-Yao,Li, Yan,&Zhu, Hua-Jie.(2011).Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(8),2302-2304.
MLA	Bai, Bing,et al."Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.8(2011):2302-2304.

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