Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives
Bai, Bing1,3; Li, Xing-Yao1,3; Li, Yan1; Zhu, Hua-Jie1,2
2011-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号21期号:8页码:2302-2304
摘要Three series of novel beta-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Beta-amino Alcohol Cytotoxic Activity Structure-activity Relationship Mtt
资助信息NSFC[30873141]; 973 Program[2009CB522300]; program of recruited science and technology talents[2009C1120]; State Key Laboratory of Phytochemistry and Plant Resources in West China; Hebei University
学科领域Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmcl.2011.02.087
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000289074700025
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5523
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China
2.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Coll Life Sci, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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GB/T 7714
Bai, Bing,Li, Xing-Yao,Li, Yan,et al. Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(8):2302-2304.
APA Bai, Bing,Li, Xing-Yao,Li, Yan,&Zhu, Hua-Jie.(2011).Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(8),2302-2304.
MLA Bai, Bing,et al."Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.8(2011):2302-2304.
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