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题名: Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives
作者: Bai, Bing1, 3; Li, Xing-Yao1, 3; null(李艳)1; Zhu, Hua-Jie1, 2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: beta-Amino alcohol ; Cytotoxic activity ; Structure-activity relationship ; MTT
英文摘要: Three series of novel beta-amino alcohols possessing an N-anthranyl group have been obtained using tryptophan as the major starting material. These compounds were screened for cytotoxic activity against five human cancer cell lines in vitro by MTT assay, and some of them exhibited potential ability to be anticancer agents. Structure-activity relationship was carefully investigated. Only the compounds possessing small substituents (H or CH(3)) at C-6 position showed the same activity as cisplatin (DDP) did. (C) 2011 Elsevier Ltd. All rights reserved.
出版日期: 2011-04-15
卷号: 21, 期号:8, 页码:2302-2304
DOI标识: 10.1016/j.bmcl.2011.02.087
语种: 英语
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5523
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Organ Synth & Nat Prod Lab, Kunming 650204, Peoples R China
2.Hebei Univ, Minist Educ, Key Lab Med Chem & Mol Diag, Coll Life Sci, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Bai, B; Li, XY; Li, Y; Zhu, HJ.Design, synthesis and cytotoxic activities of novel beta-amino alcohol derivatives,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(8):2302-2304
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