| Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production | |
| Zhang, Wenpeng1; Xia, Chengfeng1,2,3; Nadas, Janos2; Chen, Wenlan2; Gu, Li1,4; Wang, Peng George1,2 | |
| 通讯作者 | Xia, CF (reprint author), Ohio State Univ, Dept Biochem, 484 W 12th Ave, Columbus, OH 43210 USA |
| 2011-04-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| ISSN | 0968-0896 |
| 卷号 | 19期号:8页码:2767-2776 |
| 摘要 | The glycosphingolipid alpha-GalCer has been found to influence mammalian immune system significantly through the natural killer T cells. Unfortunately, the pre-clinical and clinical studies revealed several critical disadvantages that prevented the therapeutic application of alpha-GalCer in treating cancer and other diseases. Recently, the detailed illustration of the CD1d/alpha-GalCer/NKT TCR complex crystal structural, together with other latest structural and biological understanding on glycolipid ligands and NKT cells, provided a new platform for developing novel glycolipid ligands with optimized therapeutic effects. Here, we designed a series of novel aromatic group substituted alpha-GalCer analogues. The biological activity of these analogues was characterized and the results showed the unique substitution group manipulated the immune responses of NKT cells. Computer modeling and simulation study indicated the analogues had unique binding mode when forming CD1d/glycolipid/NKT TCR complex, comparing to original alpha-GalCer. (C) 2010 Published by Elsevier Ltd. |
| 关键词 | Alpha-galcer Nkt Cell Ligand Computer Modeling Cd1d Nkt Tcr |
| 学科领域 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmc.2010.11.061 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289281600030 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5519 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA 2.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 4.Shandong Univ, SKLMT, Jinan 250100, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,et al. Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(8):2767-2776. |
| APA | Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,Chen, Wenlan,Gu, Li,&Wang, Peng George.(2011).Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production.BIOORGANIC & MEDICINAL CHEMISTRY,19(8),2767-2776. |
| MLA | Zhang, Wenpeng,et al."Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production".BIOORGANIC & MEDICINAL CHEMISTRY 19.8(2011):2767-2776. |
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