Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production
Zhang, Wenpeng1; Xia, Chengfeng1,2,3; Nadas, Janos2; Chen, Wenlan2; Gu, Li1,4; Wang, Peng George1,2
2011-04-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号19期号:8页码:2767-2776
摘要The glycosphingolipid alpha-GalCer has been found to influence mammalian immune system significantly through the natural killer T cells. Unfortunately, the pre-clinical and clinical studies revealed several critical disadvantages that prevented the therapeutic application of alpha-GalCer in treating cancer and other diseases. Recently, the detailed illustration of the CD1d/alpha-GalCer/NKT TCR complex crystal structural, together with other latest structural and biological understanding on glycolipid ligands and NKT cells, provided a new platform for developing novel glycolipid ligands with optimized therapeutic effects. Here, we designed a series of novel aromatic group substituted alpha-GalCer analogues. The biological activity of these analogues was characterized and the results showed the unique substitution group manipulated the immune responses of NKT cells. Computer modeling and simulation study indicated the analogues had unique binding mode when forming CD1d/glycolipid/NKT TCR complex, comparing to original alpha-GalCer. (C) 2010 Published by Elsevier Ltd.
关键词Alpha-galcer Nkt Cell Ligand Computer Modeling Cd1d Nkt Tcr
资助信息National Institutes of Health[R21AI083513]; State Key Laboratory of Phytochemistry & Plant Resources in West China
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5519
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA
2.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
4.Shandong Univ, SKLMT, Jinan 250100, Shandong, Peoples R China
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Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,et al. Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(8):2767-2776.
APA Zhang, Wenpeng,Xia, Chengfeng,Nadas, Janos,Chen, Wenlan,Gu, Li,&Wang, Peng George.(2011).Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production.BIOORGANIC & MEDICINAL CHEMISTRY,19(8),2767-2776.
MLA Zhang, Wenpeng,et al."Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production".BIOORGANIC & MEDICINAL CHEMISTRY 19.8(2011):2767-2776.
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