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题名: Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production
作者: Zhang, Wenpeng1; null(夏成峰)1, 2, 3; Nadas, Janos2; Chen, Wenlan2; Gu, Li1, 4; Wang, Peng George1, 2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: alpha-GalCer ; NKT cell ligand ; Computer modeling ; CD1d ; NKT TCR
英文摘要: The glycosphingolipid alpha-GalCer has been found to influence mammalian immune system significantly through the natural killer T cells. Unfortunately, the pre-clinical and clinical studies revealed several critical disadvantages that prevented the therapeutic application of alpha-GalCer in treating cancer and other diseases. Recently, the detailed illustration of the CD1d/alpha-GalCer/NKT TCR complex crystal structural, together with other latest structural and biological understanding on glycolipid ligands and NKT cells, provided a new platform for developing novel glycolipid ligands with optimized therapeutic effects. Here, we designed a series of novel aromatic group substituted alpha-GalCer analogues. The biological activity of these analogues was characterized and the results showed the unique substitution group manipulated the immune responses of NKT cells. Computer modeling and simulation study indicated the analogues had unique binding mode when forming CD1d/glycolipid/NKT TCR complex, comparing to original alpha-GalCer. (C) 2010 Published by Elsevier Ltd.
出版日期: 2011-04-15
卷号: 19, 期号:8, 页码:2767-2776
DOI标识: 10.1016/j.bmc.2010.11.061
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
ISSN号: 0968-0896
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5519
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA
2.Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
4.Shandong Univ, SKLMT, Jinan 250100, Shandong, Peoples R China

Recommended Citation:
Zhang, WP; Xia, CF; Nadas, J; Chen, WL; Gu, L; Wang, PG.Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production,BIOORGANIC & MEDICINAL CHEMISTRY,2011,19(8):2767-2776
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