Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities
Mu, Huai-Xue1,2,3,4; Li, Xue-Sen1,2,4; Fan, Peng1,2,4; Yang, Guang-Yu1,2,3,4; Pu, Jian-Xin3; Sun, Han-Dong3; Hu, Qiu-Fen1,2; Xiao, Wei-Lie3
2011
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号13期号:5页码:393-399
摘要Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC50 values of 2.26 and 1.82g/ml, and therapeutic index values of 35.5 and 18.6, respectively.
关键词Schisandreae Schisandra Rubriflora Fruits Dibenzocyclooctadiene Lignans Anti-hiv-1 Activity
资助信息National Natural Science Foundation of China[30830115, 20802082]; Chinese Academy of Sciences[KSCX1-YW-R-24]; 973 programs[2009CB522300, 2009CB940900]; Young Academic and Technical Leader Rising Foundation of Yunnan Province[2006PY01-47]
学科领域Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
DOI10.1080/10286020.2011.565748
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000290046300002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5503
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
2.Minist Educ, Kunming 650031, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China
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Mu, Huai-Xue,Li, Xue-Sen,Fan, Peng,et al. Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(5):393-399.
APA Mu, Huai-Xue.,Li, Xue-Sen.,Fan, Peng.,Yang, Guang-Yu.,Pu, Jian-Xin.,...&Xiao, Wei-Lie.(2011).Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(5),393-399.
MLA Mu, Huai-Xue,et al."Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.5(2011):393-399.
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