New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia
Hua, Juan1,2,3,4; Luo, Shi-Hong3; Liu, Yan3; Liu, Yan-Chun3; Tan, Yan-Yun3,4; Feng, Ling3,4; Xiao, Chao-Jiang3,4; Zhang, Ke-Qin1,2; Li, Sheng-Hong3; Niu, Xue-Mei1,2
2017-10-01
Source PublicationCHEMISTRY & BIODIVERSITY
ISSN1612-1872
Volume14Issue:10Pages:1
AbstractThree new macrocyclic diterpenoids, euphoscopoids A - C (1 - 3), including two new jatrophanes and a new lathyrane, were isolated from the whole plant of Euphorbia helioscopia. Their structures were elucidated by spectroscopic methods. Antifeedant and cytotoxic activities of these isolates were evaluated. All compounds showed significant antifeedant activity against a generalist plant-feeding insect, Helicoverpa armigera, with EC50 values ranging from 2.05 to 4.34 mu g/cm(2). In addition, compound 2 showed moderate cytotoxicity against tumor cell lines NCI-H1975, HepG2, and MCF-2, while compounds 1 and 3 were not active at 80 mu M. The results suggested not only the defensive function of macrocyclic diterpenoids in E. helioscopia against insect herbivores, but also their potential applications as new natural insect antifeedants.
KeywordEuphorbia Helioscopia Euphoscopoids a -c Diterpenoids Antifeedant Activities Cytotoxic Activities.
DOI10.1002/cbdv.201700327
Indexed BySCI
Language英语
WOS IDWOS:000417435200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54986
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Yunnan Univ, Sch Life Sci, Minist Educ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ, Sch Life Sci, Minist Educ, Key Lab Microbial Resources, Kunming 650091, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Hua, Juan,Luo, Shi-Hong,Liu, Yan,et al. New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia[J]. CHEMISTRY & BIODIVERSITY,2017,14(10):1.
APA Hua, Juan.,Luo, Shi-Hong.,Liu, Yan.,Liu, Yan-Chun.,Tan, Yan-Yun.,...&Niu, Xue-Mei.(2017).New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia.CHEMISTRY & BIODIVERSITY,14(10),1.
MLA Hua, Juan,et al."New Bioactive Macrocyclic Diterpenoids from Euphorbia helioscopia".CHEMISTRY & BIODIVERSITY 14.10(2017):1.
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