| Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida | |
Nian, Yin ; Yan, Hui; Li, Xiao-Nian; Zhou, Lin; Qiu, Ming-Hua
| |
| 2017 | |
| Source Publication | RSC ADVANCES
 |
| ISSN | 2046-2069 |
| Volume | 7Issue:61Pages:38557-38564 |
| Abstract | Seven new dahurinol-type triterpene derivatives, including three aglycones, cimifrigines A-C (1-3), and four glycosides, cimifrigines D-G (4-7), were purified from the flowers of Cimicifuga frigida. These triterpenoids are characterized by an oxime group at C-15. Spectroscopic analyses and X-ray crystallography were used to determine the new structures. In the in vitro cytotoxicity screening, glycosides (4-7) exhibited more noticeable activities than the aglycones (1-3) against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines. Interestingly, compounds 5 and 7, bearing a 2'-O-acetyl moiety on the sugar unit, showed comparable cytotoxicities to the positive control, cisplatin (IC50: 0.5 to 5.4 mu M). Whereas, analogues 4 and 6, without the 2'-O-acetyl group, indicated weaker activities with IC50 values ranging from 8.9 to 14.3 mu M. |
| Keyword | Aerial Parts Cimifuga-foetida 9 Black Cohosh 19-cyclolanostane Derivatives Rhizomes Glycosides Constituents Yunnanensis Racemosa Saponins |
| Subject Area | Chemistry, Multidisciplinary |
| DOI | 10.1039/c7ra07275a |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000407442000053 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/54978 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Nian, Yin,Yan, Hui,Li, Xiao-Nian,et al. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida[J]. RSC ADVANCES,2017,7(61):38557-38564. |
| APA | Nian, Yin,Yan, Hui,Li, Xiao-Nian,Zhou, Lin,&Qiu, Ming-Hua.(2017).Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida.RSC ADVANCES,7(61),38557-38564. |
| MLA | Nian, Yin,et al."Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida".RSC ADVANCES 7.61(2017):38557-38564. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| nian2017.pdf（767KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment