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题名: Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida
作者: Nian,Yin; Yan,Hui; Li,Xiao-Nian; Zhou,Lin; Qiu,Ming-Hua
刊名: RSC ADVANCES
关键词: AERIAL PARTS ; 9,19-CYCLOLANOSTANE DERIVATIVES ; CIMIFUGA-FOETIDA ; BLACK COHOSH ; RHIZOMES ; GLYCOSIDES ; CONSTITUENTS ; YUNNANENSIS ; RACEMOSA ; SAPONINS
英文摘要: Seven new dahurinol-type triterpene derivatives, including three aglycones, cimifrigines A-C (1-3), and four glycosides, cimifrigines D-G (4-7), were purified from the flowers of Cimicifuga frigida. These triterpenoids are characterized by an oxime group at C-15. Spectroscopic analyses and X-ray crystallography were used to determine the new structures. In the in vitro cytotoxicity screening, glycosides (4-7) exhibited more noticeable activities than the aglycones (1-3) against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines. Interestingly, compounds 5 and 7, bearing a 2'-O-acetyl moiety on the sugar unit, showed comparable cytotoxicities to the positive control, cisplatin (IC50: 0.5 to 5.4 mu M). Whereas, analogues 4 and 6, without the 2'-O-acetyl group, indicated weaker activities with IC50 values ranging from 8.9 to 14.3 mu M.
出版日期: 2017
卷号: 7, 期号:61, 页码:38557-38564
DOI标识: 10.1039/c7ra07275a
语种: 英语
收录类别: SCI
学科分类: Chemistry, Multidisciplinary
通讯作者邮箱: mhchiu@mail.kib.ac.cn
ISSN号: 2046-2069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54978
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Nian,Yin,Yan,Hui,Li,Xiao-Nian,et al. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida[J]. RSC ADVANCES,2017,7(61):38557-38564.
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