Seven new dahurinol-type triterpene derivatives, including three aglycones, cimifrigines A-C (1-3), and four glycosides, cimifrigines D-G (4-7), were purified from the flowers of Cimicifuga frigida. These triterpenoids are characterized by an oxime group at C-15. Spectroscopic analyses and X-ray crystallography were used to determine the new structures. In the in vitro cytotoxicity screening, glycosides (4-7) exhibited more noticeable activities than the aglycones (1-3) against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines. Interestingly, compounds 5 and 7, bearing a 2'-O-acetyl moiety on the sugar unit, showed comparable cytotoxicities to the positive control, cisplatin (IC50: 0.5 to 5.4 mu M). Whereas, analogues 4 and 6, without the 2'-O-acetyl group, indicated weaker activities with IC50 values ranging from 8.9 to 14.3 mu M.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation:
Nian,Yin,Yan,Hui,Li,Xiao-Nian,et al. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida[J]. RSC ADVANCES,2017,7(61):38557-38564.
