Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida

doi:10.1039/c7ra07275a

	Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida
	Nian, Yin; Yan, Hui; Li, Xiao-Nian; Zhou, Lin; Qiu, Ming-Hua
	2017
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	7 期号:61 页码:38557-38564
摘要	Seven new dahurinol-type triterpene derivatives, including three aglycones, cimifrigines A-C (1-3), and four glycosides, cimifrigines D-G (4-7), were purified from the flowers of Cimicifuga frigida. These triterpenoids are characterized by an oxime group at C-15. Spectroscopic analyses and X-ray crystallography were used to determine the new structures. In the in vitro cytotoxicity screening, glycosides (4-7) exhibited more noticeable activities than the aglycones (1-3) against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines. Interestingly, compounds 5 and 7, bearing a 2'-O-acetyl moiety on the sugar unit, showed comparable cytotoxicities to the positive control, cisplatin (IC50: 0.5 to 5.4 mu M). Whereas, analogues 4 and 6, without the 2'-O-acetyl group, indicated weaker activities with IC50 values ranging from 8.9 to 14.3 mu M.
关键词	Aerial Parts Cimifuga-foetida 9 Black Cohosh 19-cyclolanostane Derivatives Rhizomes Glycosides Constituents Yunnanensis Racemosa Saponins
学科领域	Chemistry, Multidisciplinary
DOI	10.1039/c7ra07275a
收录类别	SCI
语种	英语
WOS记录号	WOS:000407442000053
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/54978
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Yan, Hui,Li, Xiao-Nian,et al. Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida[J]. RSC ADVANCES,2017,7(61):38557-38564.
APA	Nian, Yin,Yan, Hui,Li, Xiao-Nian,Zhou, Lin,&Qiu, Ming-Hua.(2017).Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida.RSC ADVANCES,7(61),38557-38564.
MLA	Nian, Yin,et al."Cimifrigines A-G, cytotoxic triterpenes with an oxime group from the flowers of Cimicifuga frigida".RSC ADVANCES 7.61(2017):38557-38564.

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