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题名: Metabolic profiling of myrislignan by UPLC-ESI-QTOFMS-based metabolomics
作者: Yang,Xiao-Nan; Lv,Qian-Qian; Zhao,Qi; Li,Xin-Mei; Yan,Dong-Mei; Yang,Xiu-Wei; Li,Fei
刊名: RSC ADVANCES
关键词: MYRISTICA-FRAGRANS ; IN-VITRO ; LIVER-MICROSOMES ; NEOLIGNANS ; EXTRACT ; LIGNANS ; PHARMACOKINETICS ; IDENTIFICATION ; NOSCAPINE ; REVEALS
英文摘要: Myrislignan (MRL) is a bioactive 8-O-4'-neolignan distributed in nutmeg that is an official Traditional Chinese Medicine used for the treatment of gastrointestinal diseases in China. In the present study, the metabolic map of MRL was determined in mouse by ultra-performance chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS)-based metabolomics. A total of 23 MRL metabolites (19 were newly identified) were determined in both in vivo and in vitro metabolism of MRL. It was found that hydroxylation and demethylation were the major metabolic pathways for MRL metabolism in vitro and in vivo, respectively. Recombinant cytochrome P450s (CYPs) screening revealed that CYP3A4 and CYP3A5 played a crucial role in the metabolism of MRL. Interestingly, MRL and its metabolites were prone to generate the high abundance ions of Na+ adducts due to one 8-O-4' type bond in their molecular structures. Taken together, these data reveal the metabolic map of MRL, contributing to the understanding of the metabolism and disposition of 8-O-4'-neolignans in nutmeg.
出版日期: 2017
卷号: 7, 期号:64, 页码:40131-40140
DOI标识: 10.1039/c7ra06189g
语种: 英语
收录类别: SCI
学科分类: Chemistry, Multidisciplinary
通讯作者邮箱: yanli1999@163.com ; lifeib@mail.kib.ac.cn
ISSN号: 2046-2069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54976
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Yang,Xiao-Nan,Lv,Qian-Qian,Zhao,Qi,et al. Metabolic profiling of myrislignan by UPLC-ESI-QTOFMS-based metabolomics[J]. RSC ADVANCES,2017,7(64):40131-40140.
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