Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds
Song, Chang-Wei1; Wang, Shu-Mei1,3; Zhou, Li-Li2; Hou, Fan-Fan2; Wang, Kai-Jin4; Han, Quan-Bin5; Li, Ning4; Cheng, Yong-Xian1
2011-02-23
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
卷号59期号:4页码:1199-1204
摘要Euryale ferox seed is consumed medicinally or for food in China. The present study revealed it to contain significant antioxidant activity, which may be associated with its medical applications as a proteinuria inhibitor of diabetic nephropathy. This; study resulted in the identification of 3 new sesquineolignans, named euryalins A-C (1-3), and 16 known compounds, which were I all first isolated from this plant apart from 5,7,4-trihydroxy-flavanone. The antioxidant potential of the partial isolates was evaluated using the DPPH radical scavenging assay and mesangial cellular assay. Compounds 2, rel-(2 alpha,3 beta)-7-O-methylcedrusin (4), syringylglycerol-8-O-4-(sinapyl alcohol) ether (5), and (+)-syringaresinol (7) were found to be most active on DPPH assay, whereas compounds 2, 4, 7, (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicydo[3.3.0]octane, and buddlenol E could significantly inhibit high glucose-stimulated reactive oxygen species production in mesangial cells. The results suggested that E. ferox seed could be considered as an excellent source of natural antioxidants and is useful in the prevention of diabetic nephropathy.
关键词Euryale Ferox Nymphaeaceae Lignans Antioxidant Activity
资助信息Ministry of Science; Technology of China[2008ZX09401-004]; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; "Talent Scholarship for the Youth of Yunnan"[2007PY01-48]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5495
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
3.Guangdong Pharmaceut Univ, Coll Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
4.Anhui Univ, Sch Life Sci, Anhui 230039, Peoples R China
5.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China
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Song, Chang-Wei,Wang, Shu-Mei,Zhou, Li-Li,et al. Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(4):1199-1204.
APA Song, Chang-Wei.,Wang, Shu-Mei.,Zhou, Li-Li.,Hou, Fan-Fan.,Wang, Kai-Jin.,...&Cheng, Yong-Xian.(2011).Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,59(4),1199-1204.
MLA Song, Chang-Wei,et al."Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 59.4(2011):1199-1204.
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