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题名: Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds
作者: Song, Chang-Wei1; Wang, Shu-Mei1, 3; Zhou, Li-Li2; Hou, Fan-Fan2; Wang, Kai-Jin4; Han, Quan-Bin5; Li, Ning4; null(程永现)1
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
关键词: Euryale ferox ; Nymphaeaceae ; lignans ; antioxidant activity
英文摘要: Euryale ferox seed is consumed medicinally or for food in China. The present study revealed it to contain significant antioxidant activity, which may be associated with its medical applications as a proteinuria inhibitor of diabetic nephropathy. This; study resulted in the identification of 3 new sesquineolignans, named euryalins A-C (1-3), and 16 known compounds, which were I all first isolated from this plant apart from 5,7,4-trihydroxy-flavanone. The antioxidant potential of the partial isolates was evaluated using the DPPH radical scavenging assay and mesangial cellular assay. Compounds 2, rel-(2 alpha,3 beta)-7-O-methylcedrusin (4), syringylglycerol-8-O-4-(sinapyl alcohol) ether (5), and (+)-syringaresinol (7) were found to be most active on DPPH assay, whereas compounds 2, 4, 7, (1R,2R,5R,6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicydo[3.3.0]octane, and buddlenol E could significantly inhibit high glucose-stimulated reactive oxygen species production in mesangial cells. The results suggested that E. ferox seed could be considered as an excellent source of natural antioxidants and is useful in the prevention of diabetic nephropathy.
出版日期: 2011-02-23
卷号: 59, 期号:4, 页码:1199-1204
DOI标识: 10.1021/jf1041933
语种: 英语
收录类别: SCI ; IC
学科分类: Agriculture; Chemistry; Food Science & Technology
ISSN号: 0021-8561
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5495
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.So Med Univ, Nanfang Hosp, Div Nephrol, Key Lab Organ Failure Res,Educ Minist, Guangzhou 510515, Guangdong, Peoples R China
3.Guangdong Pharmaceut Univ, Coll Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
4.Anhui Univ, Sch Life Sci, Anhui 230039, Peoples R China
5.Chinese Univ Hong Kong, Inst Chinese Med, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Song, CW; Wang, SM; Zhou, LL; Hou, FF; Wang, KJ; Han, QB; Li, N; Cheng, YX.Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011,59(4):1199-1204
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