Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity
Jiang, Hua-Yi1,2,3,4; Wang, Wei-Guang1,2; Tang, Jian-Wei1,2; Liu, Miao1,2; Li, Xing-Ren1,2; Hu, Kun1,2; Du, Xue1,2; Li, Xiao-Nian1,2; Zhang, Hong-Bin4; Pu, Jian-Xin1,2; Sun, Han-Dong1,2
2017-07-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume80Issue:7Pages:2026-2036
AbstractFourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 mu M, respectively.
KeywordEnt-kaurane Diterpenoids Isodon-scoparius Cytotoxic Diterpenoids Abietane Diterpenoids Eriocalyxin-b Derivatives Laxiflora Growth
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/acs.jnatprod.7b00163
Indexed BySCI
Language英语
WOS IDWOS:000406818300009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54947
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Hua-Yi,Wang, Wei-Guang,Tang, Jian-Wei,et al. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2026-2036.
APA Jiang, Hua-Yi.,Wang, Wei-Guang.,Tang, Jian-Wei.,Liu, Miao.,Li, Xing-Ren.,...&Sun, Han-Dong.(2017).Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity.JOURNAL OF NATURAL PRODUCTS,80(7),2026-2036.
MLA Jiang, Hua-Yi,et al."Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2026-2036.
Files in This Item: Download All
File Name/Size DocType Version Access License
13.pdf(1786KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jiang, Hua-Yi]'s Articles
[Wang, Wei-Guang]'s Articles
[Tang, Jian-Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jiang, Hua-Yi]'s Articles
[Wang, Wei-Guang]'s Articles
[Tang, Jian-Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jiang, Hua-Yi]'s Articles
[Wang, Wei-Guang]'s Articles
[Tang, Jian-Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 13.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.