| Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity | |
Jiang, Hua-Yi1,2,3,4; Wang, Wei-Guang1,2; Tang, Jian-Wei1,2; Liu, Miao1,2; Li, Xing-Ren1,2; Hu, Kun1,2 ; Du, Xue1,2; Li, Xiao-Nian1,2; Zhang, Hong-Bin4; Pu, Jian-Xin1,2; Sun, Han-Dong1,2
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| 2017-07-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 80期号:7页码:2026-2036 |
| 摘要 | Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 mu M, respectively. |
| 关键词 | Ent-kaurane Diterpenoids Isodon-scoparius Cytotoxic Diterpenoids Abietane Diterpenoids Eriocalyxin-b Derivatives Laxiflora Growth |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/acs.jnatprod.7b00163 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000406818300009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54947 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Hua-Yi,Wang, Wei-Guang,Tang, Jian-Wei,et al. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2026-2036. |
| APA | Jiang, Hua-Yi.,Wang, Wei-Guang.,Tang, Jian-Wei.,Liu, Miao.,Li, Xing-Ren.,...&Sun, Han-Dong.(2017).Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity.JOURNAL OF NATURAL PRODUCTS,80(7),2026-2036. |
| MLA | Jiang, Hua-Yi,et al."Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2026-2036. |
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| 13.pdf（1786KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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