Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity
Jiang, Hua-Yi1,2,3,4; Wang, Wei-Guang1,2; Tang, Jian-Wei1,2; Liu, Miao1,2; Li, Xing-Ren1,2; Hu, Kun1,2; Du, Xue1,2; Li, Xiao-Nian1,2; Zhang, Hong-Bin4; Pu, Jian-Xin1,2; Sun, Han-Dong1,2
2017-07-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号80期号:7页码:2026-2036
摘要Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values of 1.0, 3.1, and 1.8 mu M, respectively.
关键词Ent-kaurane Diterpenoids Isodon-scoparius Cytotoxic Diterpenoids Abietane Diterpenoids Eriocalyxin-b Derivatives Laxiflora Growth
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/acs.jnatprod.7b00163
收录类别SCI
语种英语
WOS记录号WOS:000406818300009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54947
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China
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Jiang, Hua-Yi,Wang, Wei-Guang,Tang, Jian-Wei,et al. Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(7):2026-2036.
APA Jiang, Hua-Yi.,Wang, Wei-Guang.,Tang, Jian-Wei.,Liu, Miao.,Li, Xing-Ren.,...&Sun, Han-Dong.(2017).Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity.JOURNAL OF NATURAL PRODUCTS,80(7),2026-2036.
MLA Jiang, Hua-Yi,et al."Structurally Diverse Diterpenoids from lsodon scoparius and Their Bioactivity".JOURNAL OF NATURAL PRODUCTS 80.7(2017):2026-2036.
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