| Selected Mutations Revealed Intermediates and Key Precursors in the Biosynthesis of Polyketide-Terpenoid Hybrid Sesquiterpenyl Epoxy-cyclohexenoids | |
Teng, Lin-Lin1,2,3; Song, Tian-Yang1,2; Xu, Zi-Fei1,2; Liu, Xiao1,2; Dai, Rong1,2; Chen, Yong-Hong1,2; Li, Sheng-Hong3 ; Zhang, Ke-Qin1,2; Niu, Xue-Mei1,2
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| 2017-07-21 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 19期号:14页码:3923-3926 |
| 摘要 | Sesquiterpenyl epoxy-cydohexenoids (SECs) show impressive biological activities. However, the key pathways for SECs still remain, unambiguous. Unexpectedly, 11 new SECs and derivatives with diverse oxidation patterns were isolated after the deletion of gene 274. A high accumulation of toluquiriol and its new glycosides in mutant Delta 276 and further isolation of the most crucial. precursors farnesy1 hydroquinone, farnesyl quinone, and three new derivatives froth mutant Delta 278-confirm that farnesylation at toluquinol is the key step for SECs. |
| 关键词 | Fungus Arthrobotrys-oligospora Morphological Regulatory Arthrosporols Metabolite Production Antibiotics Disruption Mechanisms Patulin |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/acs.orglett.7b01846 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000406356500060 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54942 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Yunnan Univ, Sch Life Sci, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ, Sch Life Sci, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Teng, Lin-Lin,Song, Tian-Yang,Xu, Zi-Fei,et al. Selected Mutations Revealed Intermediates and Key Precursors in the Biosynthesis of Polyketide-Terpenoid Hybrid Sesquiterpenyl Epoxy-cyclohexenoids[J]. ORGANIC LETTERS,2017,19(14):3923-3926. |
| APA | Teng, Lin-Lin.,Song, Tian-Yang.,Xu, Zi-Fei.,Liu, Xiao.,Dai, Rong.,...&Niu, Xue-Mei.(2017).Selected Mutations Revealed Intermediates and Key Precursors in the Biosynthesis of Polyketide-Terpenoid Hybrid Sesquiterpenyl Epoxy-cyclohexenoids.ORGANIC LETTERS,19(14),3923-3926. |
| MLA | Teng, Lin-Lin,et al."Selected Mutations Revealed Intermediates and Key Precursors in the Biosynthesis of Polyketide-Terpenoid Hybrid Sesquiterpenyl Epoxy-cyclohexenoids".ORGANIC LETTERS 19.14(2017):3923-3926. |
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