Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis
Ye, Qingqing1,2; Tian, Haifeng1; Chen, Bing1; Shao, Jingru1; Qin, Yan1,3; Wen, Jianfan1
2017-08-25
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Pages:9507
AbstractGiardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for years. Glycerophospholipid (GPL) synthesis is a conserved essential cellular process, and thus may retain some original features reflecting its evolutionary position, and this process should also have undergone parasitic adaptation to suit Giardia's dietary lipid-rich environment. Thus, GPL synthesis pathways may be a perfect object to examine the controversy over Giardia. Here, we first clarified Giardia's previously confusing GPL synthesis by re-identifying a reliable set of GPL synthesis genes/enzymes. Then using phylogenetic and comparative genomic analyses, we revealed that these pathways turn out to be evolutionarily primitive ones, but with many secondary parasitic adaptation 'patches' including gene loss, rapid evolution, product relocation, and horizontal gene transfer. Therefore, modern Giardia should be a mosaic of 'primary primitivity' and 'secondary parasitic adaptability', and to make a distinction between the two categories of features would restart the studies of eukaryotic evolution and parasitic adaptation using Giardia as a model system.
KeywordEarly-branching Eukaryote Best-fit Models Protein Evolution Lipid-metabolism Cell Biology Lamblia Phosphatase Phosphatidylethanolamine Phosphatidylglycerol Phospholipids
Subject AreaMultidisciplinary Sciences
DOI10.1038/s41598-017-10054-1
Indexed BySCI
Language英语
WOS IDWOS:000408448600044
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54913
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Ye, Qingqing,Tian, Haifeng,Chen, Bing,et al. Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis[J]. SCIENTIFIC REPORTS,2017,7:9507.
APA Ye, Qingqing,Tian, Haifeng,Chen, Bing,Shao, Jingru,Qin, Yan,&Wen, Jianfan.(2017).Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis.SCIENTIFIC REPORTS,7,9507.
MLA Ye, Qingqing,et al."Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis".SCIENTIFIC REPORTS 7(2017):9507.
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