Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis
Ye, Qingqing1,2; Tian, Haifeng1; Chen, Bing1; Shao, Jingru1; Qin, Yan1,3; Wen, Jianfan1
2017-08-25
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号7页码:9507
摘要Giardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for years. Glycerophospholipid (GPL) synthesis is a conserved essential cellular process, and thus may retain some original features reflecting its evolutionary position, and this process should also have undergone parasitic adaptation to suit Giardia's dietary lipid-rich environment. Thus, GPL synthesis pathways may be a perfect object to examine the controversy over Giardia. Here, we first clarified Giardia's previously confusing GPL synthesis by re-identifying a reliable set of GPL synthesis genes/enzymes. Then using phylogenetic and comparative genomic analyses, we revealed that these pathways turn out to be evolutionarily primitive ones, but with many secondary parasitic adaptation 'patches' including gene loss, rapid evolution, product relocation, and horizontal gene transfer. Therefore, modern Giardia should be a mosaic of 'primary primitivity' and 'secondary parasitic adaptability', and to make a distinction between the two categories of features would restart the studies of eukaryotic evolution and parasitic adaptation using Giardia as a model system.
关键词Early-branching Eukaryote Best-fit Models Protein Evolution Lipid-metabolism Cell Biology Lamblia Phosphatase Phosphatidylethanolamine Phosphatidylglycerol Phospholipids
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54913
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
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Ye, Qingqing,Tian, Haifeng,Chen, Bing,et al. Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis[J]. SCIENTIFIC REPORTS,2017,7:9507.
APA Ye, Qingqing,Tian, Haifeng,Chen, Bing,Shao, Jingru,Qin, Yan,&Wen, Jianfan.(2017).Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis.SCIENTIFIC REPORTS,7,9507.
MLA Ye, Qingqing,et al."Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis".SCIENTIFIC REPORTS 7(2017):9507.
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