Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa
Yuan, Yu-Xi1,3; Zhang, Yu1; Guo, Ling-Li1; Wang, Yue-Hu2; Goto, Masuo4; Morris-Natschke, Susan L.4; Lee, Kuo-Hsiung4,5; Hao, Xiao-Jiang1
2017-09-15
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume19Issue:18Pages:4964-4967
AbstractTabercorymines A (1) and B (2), two new vobasinyl-ibogan-type bisindole alkaloids with.an unprecedented skeleton, were isolated from Tabernaemontana corymbosa. Their structures were established by a combination of spectroscopic data, chemical transformation, single-crystal X-ray diffraction, and ECD calculation. Compound 1 represents a novel bisindole alkaloid, characterized by a caged heteropentacyclic ring system incorporating an unprecedented C-7/C-20 bond in the vobasinyl unit. Alkaloids 1 and 2 showed potent antiproliferative activity against several human cancer cell lines, including vincristine-resistant KB.
KeywordIndole Alkaloids
Subject AreaChemistry, Organic
DOI10.1021/acs.orglett.7b02445
Indexed BySCI
Language英语
WOS IDWOS:000411304300066
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54882
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
4.Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
5.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, 2 Yuh Der Rd, Taichung 40447, Taiwan
Recommended Citation
GB/T 7714
Yuan, Yu-Xi,Zhang, Yu,Guo, Ling-Li,et al. Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa[J]. ORGANIC LETTERS,2017,19(18):4964-4967.
APA Yuan, Yu-Xi.,Zhang, Yu.,Guo, Ling-Li.,Wang, Yue-Hu.,Goto, Masuo.,...&Hao, Xiao-Jiang.(2017).Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa.ORGANIC LETTERS,19(18),4964-4967.
MLA Yuan, Yu-Xi,et al."Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa".ORGANIC LETTERS 19.18(2017):4964-4967.
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