Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma
Yang, Jian-Hong1,5; Zhang, Hai-Yan2; Wen, Jin3; Du, Xue1; Chen, Jian-Hua4; Zhang, Hai-Bo1; Xiao, Wei-Lie1; Pu, Jian-Xin1; Tang, Xi-Can2; Sun, Han-Dong1
2011-05-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:5页码:1028-1035
摘要Fourteen new dibenzocyclooctadiene lignans, ananolignans A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ana iosma. The structures and absolute configurations of 1-14 were established using a combination of spectroscopic methods including 1D- and 2D-NMR and CD techniques. The biological activity of the isolated lignans was evaluated, and ananolignan F (6) and ananolignan L (12) showed significant neuroprotective effects in an in vitro assay.
关键词Schizandra-chinensis Baill Gomisin-g Interior Cells Philippinensis Constituents Coccinea Protects
资助信息NSFC[30830115, 20902093]; Science and Technology Program of Yunan Province[2008GA031]; Major State Basic Research Development Program of China[2009CB522300, 200940900]; Western Doctoral Foundation of Chinese Academy of Sciences[KZCX2-XB2-15]; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program of China"[2009ZX09301-001, -063]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np1009288
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000291127900017
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5467
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Inst Trop Forestry, Yunnan Acad Forest Sci, Kunming 650204, Peoples R China
4.Yunnan Acad Tobacco Sci, Kunming 650106, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Yang, Jian-Hong,Zhang, Hai-Yan,Wen, Jin,et al. Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(5):1028-1035.
APA Yang, Jian-Hong.,Zhang, Hai-Yan.,Wen, Jin.,Du, Xue.,Chen, Jian-Hua.,...&Sun, Han-Dong.(2011).Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma.JOURNAL OF NATURAL PRODUCTS,74(5),1028-1035.
MLA Yang, Jian-Hong,et al."Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma".JOURNAL OF NATURAL PRODUCTS 74.5(2011):1028-1035.
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