A New Tetracyclic Diterpene from Jatropha curcas

	A New Tetracyclic Diterpene from Jatropha curcas
	Xu, Jun-Ju 1,2; Fan, Jun-Ting 1; Zeng, Guang-Zhi 1; Tan, Ning-Hua 1
通讯作者	Tan, NH (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
	2011-05-01
发表期刊	HELVETICA CHIMICA ACTA
ISSN	0018-019X
卷号	94 期号:5 页码:842-846
摘要	Jatrophodione A (1), a new diterpene with four rings, together with nine known compounds, caniojane (2), jatropholone A (3), jatropholone B (4), jatrogrossidione (5), 2-epijatrogrossidione (6), heudelotinone (7), gossweilone (8), (3 alpha)-3-hydroxy-ent-pimara-8(14), 15-dien-12-one (9), and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one (10), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9, and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8, and 9 were tested on the three cancer cell lines A549, Hela, and SMMC-7721. Results showed that 7 exhibited cytotoxicity against SMMC-7721 with an IC(50) value of 21.68 mu m, whereas 7 and 8 were active against A549 with the IC(50) values of 16.04 and 20.47 mu m, and against Hela with the IC(50) values of 10.67 and 22.83 mu m, respectively.
关键词	Grossidentata
学科领域	Chemistry
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000290444900012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5425
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jun-Ju,Fan, Jun-Ting,Zeng, Guang-Zhi,et al. A New Tetracyclic Diterpene from Jatropha curcas[J]. HELVETICA CHIMICA ACTA,2011,94(5):842-846.
APA	Xu, Jun-Ju,Fan, Jun-Ting,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2011).A New Tetracyclic Diterpene from Jatropha curcas.HELVETICA CHIMICA ACTA,94(5),842-846.
MLA	Xu, Jun-Ju,et al."A New Tetracyclic Diterpene from Jatropha curcas".HELVETICA CHIMICA ACTA 94.5(2011):842-846.

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