A New Tetracyclic Diterpene from Jatropha curcas
Xu, Jun-Ju1,2; Fan, Jun-Ting1; Zeng, Guang-Zhi1; Tan, Ning-Hua1
2011-05-01
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号94期号:5页码:842-846
摘要Jatrophodione A (1), a new diterpene with four rings, together with nine known compounds, caniojane (2), jatropholone A (3), jatropholone B (4), jatrogrossidione (5), 2-epijatrogrossidione (6), heudelotinone (7), gossweilone (8), (3 alpha)-3-hydroxy-ent-pimara-8(14), 15-dien-12-one (9), and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one (10), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9, and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8, and 9 were tested on the three cancer cell lines A549, Hela, and SMMC-7721. Results showed that 7 exhibited cytotoxicity against SMMC-7721 with an IC(50) value of 21.68 mu m, whereas 7 and 8 were active against A549 with the IC(50) values of 16.04 and 20.47 mu m, and against Hela with the IC(50) values of 10.67 and 22.83 mu m, respectively.
关键词Grossidentata
资助信息National Natural Science Foundation of China[30725048]; National Basic Research Program of China[2009 CB522300]; Chinese Academy of Sciences[KSCX2-YW-R-177]; Science and Technology Department of Yunnan Province[2008OC011]
学科领域Chemistry
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000290444900012
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5425
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China
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Xu, Jun-Ju,Fan, Jun-Ting,Zeng, Guang-Zhi,et al. A New Tetracyclic Diterpene from Jatropha curcas[J]. HELVETICA CHIMICA ACTA,2011,94(5):842-846.
APA Xu, Jun-Ju,Fan, Jun-Ting,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2011).A New Tetracyclic Diterpene from Jatropha curcas.HELVETICA CHIMICA ACTA,94(5),842-846.
MLA Xu, Jun-Ju,et al."A New Tetracyclic Diterpene from Jatropha curcas".HELVETICA CHIMICA ACTA 94.5(2011):842-846.
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