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题名: A New Tetracyclic Diterpene from Jatropha curcas
作者: Xu, Jun-Ju1, 2; Fan, Jun-Ting1; Zeng, Guang-Zhi1; Tan, Ning-Hua1
刊名: HELVETICA CHIMICA ACTA
关键词: GROSSIDENTATA
英文摘要: Jatrophodione A (1), a new diterpene with four rings, together with nine known compounds, caniojane (2), jatropholone A (3), jatropholone B (4), jatrogrossidione (5), 2-epijatrogrossidione (6), heudelotinone (7), gossweilone (8), (3 alpha)-3-hydroxy-ent-pimara-8(14), 15-dien-12-one (9), and 12-hydroxy-13-methylpodocarpa-8,11,13-trien-3-one (10), was isolated from the aerial parts of Jatropha curcas. Compounds 5, 6, 9, and 10 were found for the first time in this plant. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1, 2, 7, 8, and 9 were tested on the three cancer cell lines A549, Hela, and SMMC-7721. Results showed that 7 exhibited cytotoxicity against SMMC-7721 with an IC(50) value of 21.68 mu m, whereas 7 and 8 were active against A549 with the IC(50) values of 16.04 and 20.47 mu m, and against Hela with the IC(50) values of 10.67 and 22.83 mu m, respectively.
出版日期: 2011-05-01
卷号: 94, 期号:5, 页码:842-846
语种: 英语
ISSN号: 0018-019X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5425
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Yunnan Agr Univ, Coll Tobacco Sci, Kunming 650201, Peoples R China

Recommended Citation:
Xu, JJ; Fan, JT; Zeng, GZ; Tan, NH.A New Tetracyclic Diterpene from Jatropha curcas,HELVETICA CHIMICA ACTA,2011,94(5):842-846
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