Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia

	Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia
	Wu, Zhao-Yuan 1,2; Li, Hai-Zhou 2; Wang, Wei-Guang 2; Li, Hong-Mei 2; Chen, Rui 3; Li, Rong-Tao 1,2; Luo, Huai-Rong3
通讯作者	Li, RT (reprint author), Kunming Univ Sci & Technol, Coll Environm Sci & Engn, Kunming 650224, Peoples R China
	2011-06-01
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	8 期号:6 页码:1182-1187
摘要	Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 mu m induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p < 0.001), indicating neuropharmacological potential.
关键词	Elliptica Hand-mazz Triterpenoid Glucoside Lyofolic Acid Constituents
学科领域	Biochemistry & Molecular Biology ; Chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000292200200016
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5415
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Univ Sci & Technol, Coll Environm Sci & Engn, Kunming 650224, Peoples R China 2.Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wu, Zhao-Yuan,Li, Hai-Zhou,Wang, Wei-Guang,et al. Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia[J]. CHEMISTRY & BIODIVERSITY,2011,8(6):1182-1187.
APA	Wu, Zhao-Yuan.,Li, Hai-Zhou.,Wang, Wei-Guang.,Li, Hong-Mei.,Chen, Rui.,...&Luo, Huai-Rong.(2011).Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia.CHEMISTRY & BIODIVERSITY,8(6),1182-1187.
MLA	Wu, Zhao-Yuan,et al."Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia".CHEMISTRY & BIODIVERSITY 8.6(2011):1182-1187.

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