Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia
Wu, Zhao-Yuan1,2; Li, Hai-Zhou2; Wang, Wei-Guang2; Li, Hong-Mei2; Chen, Rui3; Li, Rong-Tao1,2; Luo, Huai-Rong3
2011-06-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号8期号:6页码:1182-1187
摘要Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 mu m induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p < 0.001), indicating neuropharmacological potential.
关键词Elliptica Hand-mazz Triterpenoid Glucoside Lyofolic Acid Constituents
资助信息National Natural Science Foundation of China[20862011]; Fok Ying Tong Education Foundation[111040]; Program for New Century Excellent Talents on University[NCET-06-0824]; Department of Science and Technology in Yunnan Province[20080A007]; Foundation for the Author of National Excellent Doctoral Dissertation of P. R. China[200780]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5415
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Univ Sci & Technol, Coll Environm Sci & Engn, Kunming 650224, Peoples R China
2.Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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Wu, Zhao-Yuan,Li, Hai-Zhou,Wang, Wei-Guang,et al. Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia[J]. CHEMISTRY & BIODIVERSITY,2011,8(6):1182-1187.
APA Wu, Zhao-Yuan.,Li, Hai-Zhou.,Wang, Wei-Guang.,Li, Hong-Mei.,Chen, Rui.,...&Luo, Huai-Rong.(2011).Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia.CHEMISTRY & BIODIVERSITY,8(6),1182-1187.
MLA Wu, Zhao-Yuan,et al."Lyonin A, a New 9,10-Secograyanotoxin from Lyonia ovalifolia".CHEMISTRY & BIODIVERSITY 8.6(2011):1182-1187.
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