| Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production | |
He, Jiang-Bo1; Yan, Yong-Ming1,2; Ma, Xiu-Jing4; Lu, Qing1; Li, Xue-Song1; Su, Jia1; Li, Yan1 ; Liu, Guang-Ming3; Cheng, Yong-Xian1
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| 通讯作者 | Cheng, YX (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China |
| 2011-12-01 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 8期号:12页码:2270-2276 |
| 摘要 | Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol (7), and (3S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-ol (8), were isolated from the 95% EtOH extract of nidus vespae, the nest of Polistes species. Their structures were identified by spectroscopic methods. Compounds 1 and 8 are new products. The absolute configuration of 1 was determined by single-crystal X-ray diffraction analysis using Flack parameter. The biological tests showed that compounds 5, 6, and 8 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values in the range of 1317 mu M, whereas the sesquiterpenes were inactive in this assay (>25 mu M). In addition, the ecological significance of the presence of neurotoxic sesquiterpene lactones in nidus vespae is briefly discussed. |
| 关键词 | Nidus Vespae Sesquiterpenoids Diarylheptanoids Inhibitors X-ray Crystallography |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.1002/cbdv.201000366 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000297791000009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5407 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China 3.Dali Univ, Coll Pharmaceut Sci, Dali, Peoples R China 4.State Food & Drug Adm, Ctr Drug Evaluat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Jiang-Bo,Yan, Yong-Ming,Ma, Xiu-Jing,et al. Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production[J]. CHEMISTRY & BIODIVERSITY,2011,8(12):2270-2276. |
| APA | He, Jiang-Bo.,Yan, Yong-Ming.,Ma, Xiu-Jing.,Lu, Qing.,Li, Xue-Song.,...&Cheng, Yong-Xian.(2011).Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production.CHEMISTRY & BIODIVERSITY,8(12),2270-2276. |
| MLA | He, Jiang-Bo,et al."Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production".CHEMISTRY & BIODIVERSITY 8.12(2011):2270-2276. |
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