Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production
He, Jiang-Bo1; Yan, Yong-Ming1,2; Ma, Xiu-Jing4; Lu, Qing1; Li, Xue-Song1; Su, Jia1; Li, Yan1; Liu, Guang-Ming3; Cheng, Yong-Xian1
2011-12-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号8期号:12页码:2270-2276
摘要Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol (7), and (3S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-ol (8), were isolated from the 95% EtOH extract of nidus vespae, the nest of Polistes species. Their structures were identified by spectroscopic methods. Compounds 1 and 8 are new products. The absolute configuration of 1 was determined by single-crystal X-ray diffraction analysis using Flack parameter. The biological tests showed that compounds 5, 6, and 8 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values in the range of 1317 mu M, whereas the sesquiterpenes were inactive in this assay (>25 mu M). In addition, the ecological significance of the presence of neurotoxic sesquiterpene lactones in nidus vespae is briefly discussed.
关键词Nidus Vespae Sesquiterpenoids Diarylheptanoids Inhibitors X-ray Crystallography
资助信息Sino-German International Collaboration Project from Yunnan Province[2009AC011]; Talent Scholarship of Yunnan Youth[2007PY01-48]; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources; Ministry of Science and Technology of China[2008ZX09401-004]
学科领域Biochemistry & Molecular Biology ; Chemistry
DOI10.1002/cbdv.201000366
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000297791000009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5407
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Dali Univ, Coll Pharmaceut Sci, Dali, Peoples R China
4.State Food & Drug Adm, Ctr Drug Evaluat, Beijing, Peoples R China
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He, Jiang-Bo,Yan, Yong-Ming,Ma, Xiu-Jing,et al. Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production[J]. CHEMISTRY & BIODIVERSITY,2011,8(12):2270-2276.
APA He, Jiang-Bo.,Yan, Yong-Ming.,Ma, Xiu-Jing.,Lu, Qing.,Li, Xue-Song.,...&Cheng, Yong-Xian.(2011).Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production.CHEMISTRY & BIODIVERSITY,8(12),2270-2276.
MLA He, Jiang-Bo,et al."Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production".CHEMISTRY & BIODIVERSITY 8.12(2011):2270-2276.
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