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题名: Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production
作者: He, Jiang-Bo1; Yan, Yong-Ming1, 2; Ma, Xiu-Jing4; Lu, Qing1; Li, Xue-Song1; Su, Jia1; null(李艳)1; Liu, Guang-Ming3; null(程永现)1
刊名: CHEMISTRY & BIODIVERSITY
关键词: Nidus vespae ; Sesquiterpenoids ; Diarylheptanoids ; Inhibitors ; X-Ray crystallography
英文摘要: Two coriamyrtin-type sesquiterpenes, fengfangin A (1) and tutin (2), and six diarylheptanoids, namely alnusone (3), centrolobol (4), muricarpone B (5), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-one (6), (3S)-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptan-3-ol (7), and (3S)-1-(4-hydroxyphenyl)-7-(3,4-dihydroxyphenyl)heptan-3-ol (8), were isolated from the 95% EtOH extract of nidus vespae, the nest of Polistes species. Their structures were identified by spectroscopic methods. Compounds 1 and 8 are new products. The absolute configuration of 1 was determined by single-crystal X-ray diffraction analysis using Flack parameter. The biological tests showed that compounds 5, 6, and 8 could inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values in the range of 1317 mu M, whereas the sesquiterpenes were inactive in this assay (>25 mu M). In addition, the ecological significance of the presence of neurotoxic sesquiterpene lactones in nidus vespae is briefly discussed.
出版日期: 2011-12-01
卷号: 8, 期号:12, 页码:2270-2276
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5407
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Dali Univ, Coll Pharmaceut Sci, Dali, Peoples R China
4.State Food & Drug Adm, Ctr Drug Evaluat, Beijing, Peoples R China

Recommended Citation:
He, JB; Yan, YM; Ma, XJ; Lu, Q; Li, XS; Su, J; Li, Y; Liu, GM; Cheng, YX.Sesquiterpenoids and Diarylheptanoids from Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production,CHEMISTRY & BIODIVERSITY,2011,8(12):2270-2276
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