| Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae) | |
Xu, Min1; Zhang, Ming1; Wang, Dong1 ; Yang, Chong-Ren1,2; Zhang, Ying-Jun1
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| 通讯作者 | Zhang, YJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 2011-10-01 | |
| 发表期刊 | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| 卷号 | 8期号:10页码:1891-1900 |
| 摘要 | Gentiana rhodantha FRANCH. ex HEMSL. (Gentianaceae), an annual herb widely distributed in the southwest of China, has been medicinally used for the treatment of inflammation, cholecystitis, and tuberculosis by the local people of its growing areas. Chemical investigation on the whole plants led to the identification of eight new phenolic compounds, rhodanthenones A-D (1-4, resp.), apigenin 7-Oglucopyranosyl-(1 -> 3)-glucopyranosyl-(1 -> 3)-glucopyranoside (5), 1,2-dihydroxy-4-methoxybenzene 1-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (6), 1,2-dihydroxy-4,6-dimethoxybenzene 1-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (7), and methyl 2-O-beta-D-glucopyranosyl-2,4,6-trihydroxybenzoate (8), together with eleven known compounds, 9-19. Their structures were determined on the basis of detailed spectroscopic analyses and chemical methods. Acetylcholinesterase (AChE) inhibition and cytotoxicity tests against five human cancer cell lines showed that only rhodanthenone D (4) and mangiferin (12) exhibited 18.4 and 13.4% of AChE inhibitory effects at a concentration of 10(-4) M, respectively, while compounds 1-5 and the known xanthones lancerin (11), mangiferin (12), and neomangiferin (13) displayed no cytotoxicity at a concentration of 40 mu M. |
| 关键词 | Acylated Secoiridoid Glucosides Glycosides Acetylcholinesterase Metagentiana Constituents Phylogeny Xanthones Sequences Genus Bark |
| 学科领域 | Biochemistry & Molecular Biology ; Chemistry |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296503800008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5405 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Weihe Biotech Lab, Yuxi 653100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Min,Zhang, Ming,Wang, Dong,et al. Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae)[J]. CHEMISTRY & BIODIVERSITY,2011,8(10):1891-1900. |
| APA | Xu, Min,Zhang, Ming,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2011).Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae).CHEMISTRY & BIODIVERSITY,8(10),1891-1900. |
| MLA | Xu, Min,et al."Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae)".CHEMISTRY & BIODIVERSITY 8.10(2011):1891-1900. |
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