Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae)
Xu, Min1; Zhang, Ming1; Wang, Dong1; Yang, Chong-Ren1,2; Zhang, Ying-Jun1
2011-10-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号8期号:10页码:1891-1900
摘要Gentiana rhodantha FRANCH. ex HEMSL. (Gentianaceae), an annual herb widely distributed in the southwest of China, has been medicinally used for the treatment of inflammation, cholecystitis, and tuberculosis by the local people of its growing areas. Chemical investigation on the whole plants led to the identification of eight new phenolic compounds, rhodanthenones A-D (1-4, resp.), apigenin 7-Oglucopyranosyl-(1 -> 3)-glucopyranosyl-(1 -> 3)-glucopyranoside (5), 1,2-dihydroxy-4-methoxybenzene 1-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (6), 1,2-dihydroxy-4,6-dimethoxybenzene 1-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (7), and methyl 2-O-beta-D-glucopyranosyl-2,4,6-trihydroxybenzoate (8), together with eleven known compounds, 9-19. Their structures were determined on the basis of detailed spectroscopic analyses and chemical methods. Acetylcholinesterase (AChE) inhibition and cytotoxicity tests against five human cancer cell lines showed that only rhodanthenone D (4) and mangiferin (12) exhibited 18.4 and 13.4% of AChE inhibitory effects at a concentration of 10(-4) M, respectively, while compounds 1-5 and the known xanthones lancerin (11), mangiferin (12), and neomangiferin (13) displayed no cytotoxicity at a concentration of 40 mu M.
关键词Acylated Secoiridoid Glucosides Glycosides Acetylcholinesterase Metagentiana Constituents Phylogeny Xanthones Sequences Genus Bark
资助信息NSFC[U0632010, 2008ZX09401-004]; Science and Technology Planning Project of Yunnan Province[2010CD106]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences[P2008-ZZ08, P2010-ZZ03]
学科领域Biochemistry & Molecular Biology ; Chemistry
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000296503800008
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5405
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Weihe Biotech Lab, Yuxi 653100, Peoples R China
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Xu, Min,Zhang, Ming,Wang, Dong,et al. Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae)[J]. CHEMISTRY & BIODIVERSITY,2011,8(10):1891-1900.
APA Xu, Min,Zhang, Ming,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2011).Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae).CHEMISTRY & BIODIVERSITY,8(10),1891-1900.
MLA Xu, Min,et al."Phenolic Compounds from the Whole Plants of Gentiana rhodantha (Gentianaceae)".CHEMISTRY & BIODIVERSITY 8.10(2011):1891-1900.
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