One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica
Liu, Jie-Qing; Wang, Cui-Fang; Li, Xing-Yao; Chen, Jian-Chao; Li, Yan; Qiu, Ming-Hua
Corresponding AuthorQiu, MH (reprint author), Chinese Acad Sci, State Key Lab Photochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2011-08-01
Source PublicationARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
Volume34Issue:8Pages:1297-1300
AbstractA new pregnane glycoside, named (20R)-O-(3)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-pregn-5-en-3 beta,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea jauanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. jauanica could replace the wild plant as an antitumor plant resource.
KeywordBrucea Javanica Pregnane Glycoside Antitumor Activity Brusatol
Subject AreaPharmacology & Pharmacy
DOI10.1007/s12272-011-0809-5
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000294789700011
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5379
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, State Key Lab Photochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,et al. One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(8):1297-1300.
APA Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,Chen, Jian-Chao,Li, Yan,&Qiu, Ming-Hua.(2011).One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica.ARCHIVES OF PHARMACAL RESEARCH,34(8),1297-1300.
MLA Liu, Jie-Qing,et al."One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica".ARCHIVES OF PHARMACAL RESEARCH 34.8(2011):1297-1300.
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