One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica
Liu, Jie-Qing; Wang, Cui-Fang; Li, Xing-Yao; Chen, Jian-Chao; Li, Yan; Qiu, Ming-Hua
2011-08-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号34期号:8页码:1297-1300
摘要A new pregnane glycoside, named (20R)-O-(3)-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-pregn-5-en-3 beta,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea jauanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. jauanica could replace the wild plant as an antitumor plant resource.
关键词Brucea Javanica Pregnane Glycoside Antitumor Activity Brusatol
资助信息Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China[P2008-ZZ05, P2010-ZZ14]; CAS[KSCX2-YW-G-038, 027, KSCX2-YW-R-194, 29, KZCX2-XB2-15-03]
学科领域Pharmacology & Pharmacy
DOI10.1007/s12272-011-0809-5
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000294789700011
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5379
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, State Key Lab Photochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,et al. One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(8):1297-1300.
APA Liu, Jie-Qing,Wang, Cui-Fang,Li, Xing-Yao,Chen, Jian-Chao,Li, Yan,&Qiu, Ming-Hua.(2011).One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica.ARCHIVES OF PHARMACAL RESEARCH,34(8),1297-1300.
MLA Liu, Jie-Qing,et al."One New Pregnane Glycoside from the Seeds of Cultivated Brucea javanica".ARCHIVES OF PHARMACAL RESEARCH 34.8(2011):1297-1300.
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