Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
Zhao, Wei1,2; Pu, Jian Xin1; Du, Xue1; Wu, Ying Li3,4; Zhao, Yong1; He, Fei1; Zhang, Hai Bo1; Xue, Yong Bo1,2; Xiao, Wei Lie1; Chen, Guo Qiang3,4; Sun, Han Dong1
Corresponding AuthorPu, JX (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2011-12-01
Source PublicationARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
Volume34Issue:12Pages:2007-2014
AbstractThree new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC(50) values of 2.52, 3.06, 2.14 mu M, respectively.
KeywordNeolignan Triterpenoid Diterpenoid Isodon Coetsa Cytotoxicity Human Tumor Cell Lines
Subject AreaPharmacology & Pharmacy
DOI10.1007/s12272-011-1201-1
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000298341800003
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/5375
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Dept Pathophysiol, Shanghai 200025, Peoples R China
4.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200025, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Wei,Pu, Jian Xin,Du, Xue,et al. Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(12):2007-2014.
APA Zhao, Wei.,Pu, Jian Xin.,Du, Xue.,Wu, Ying Li.,Zhao, Yong.,...&Sun, Han Dong.(2011).Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity.ARCHIVES OF PHARMACAL RESEARCH,34(12),2007-2014.
MLA Zhao, Wei,et al."Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity".ARCHIVES OF PHARMACAL RESEARCH 34.12(2011):2007-2014.
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