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题名: Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
作者: Zhao, Wei1, 2; Pu, Jian Xin1; Du, Xue1; Wu, Ying Li3, 4; Zhao, Yong1; He, Fei1; Zhang, Hai Bo1; Xue, Yong Bo1, 2; Xiao, Wei Lie1; Chen, Guo Qiang3, 4; Sun, Han Dong1
刊名: ARCHIVES OF PHARMACAL RESEARCH
关键词: Neolignan ; Triterpenoid ; Diterpenoid ; Isodon coetsa ; Cytotoxicity ; Human tumor cell lines
英文摘要: Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC(50) values of 2.52, 3.06, 2.14 mu M, respectively.
出版日期: 2011-12-01
卷号: 34, 期号:12, 页码:2007-2014
语种: 英语
收录类别: SCI
学科分类: Pharmacology & Pharmacy
ISSN号: 0253-6269
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5375
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Dept Pathophysiol, Shanghai 200025, Peoples R China
4.Shanghai JiaoTong Univ Sch Med SJTU SM Coll, Chinese Minist Educ, Key Lab Cell Differentiat & Apoptosis, Shanghai 200025, Peoples R China

Recommended Citation:
Zhao, W; Pu, JX; Du, X; Wu, YL; Zhao, Y; He, F; Zhang, HB; Xue, YB; Xiao, WL; Chen, GQ; Sun, HD.Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity,ARCHIVES OF PHARMACAL RESEARCH,2011,34(12):2007-2014
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