Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases
Xu, Wenyan1,2,3; Li, Liling2; Du, Liangcheng1; Tan, Ninghua2
2011-10-01
发表期刊ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN1672-9145
卷号43期号:10页码:757-762
摘要An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.
关键词Ribosomal Peptide Cyclopeptides Non-ribosomal Peptide Synthetase Cyclization Mechanism
资助信息National Natural Science Foundation of China[30725048, U1032602, 91013002]; Chinese Academy of Sciences[KSCX2-YW-R-177]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Nebraska Research Council; National Institute of Health of USA[RR015468-01]; China Scholarship Council
学科领域Biochemistry & Molecular Biology ; Biophysics
DOI10.1093/abbs/gmr062
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000295411300002
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5373
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Xu, Wenyan,Li, Liling,Du, Liangcheng,et al. Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(10):757-762.
APA Xu, Wenyan,Li, Liling,Du, Liangcheng,&Tan, Ninghua.(2011).Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,43(10),757-762.
MLA Xu, Wenyan,et al."Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 43.10(2011):757-762.
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