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题名: Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases
作者: Xu, Wenyan1, 2, 3; Li, Liling2; Du, Liangcheng1; Tan, Ninghua2
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
关键词: ribosomal peptide ; cyclopeptides ; non-ribosomal peptide synthetase ; cyclization mechanism
英文摘要: An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.
出版日期: 2011-10-01
卷号: 43, 期号:10, 页码:757-762
DOI标识: 10.1093/abbs/gmr062
语种: 英语
ISSN号: 1672-9145
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5373
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Xu, WY; Li, LL; Du, LC; Tan, NH.Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases,ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(10):757-762
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