| Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus | |
Nian, Yin1,2 ; Zhang, Xian-Min2; Li, Yan2; Wang, Yuan-Yuan2; Chen, Jian-Chao2; Lu, Lu1,2; Zhou, Lin2; Qiu, Ming-Hua1
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| Corresponding Author | Qiu, MH (reprint author), Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 2011-08-01 | |
| Source Publication | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| Volume | 72Issue:11-12Pages:1473-1481 |
| Abstract | Cycloartane triterpenoids, 2',24-O-diacetylisodahurinol-3-O-alpha-L-arabinopyranoside, 24-O-acetylisodahurinol-3-O-alpha-L-arabinopyranoside, 12 beta-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12 beta-hydroxy-15-deoxycimigenol, 2'-O-acetyl-24-epi-cimigenol-3-O-alpha-L-arabinopyranoside, 2'-O-acetylcimigenol-3-O-beta-D-xylopyranoside, 25-anhydrocimigenol-3-O-alpha-L-arabinopyranoside, 2',23-O-diacetylshenginanol-3-O-alpha-L-arabinopyranoside, and 2',24-O-diacetyl-25-anhydrohydroshengmanol-3-O-alpha-L-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC(50) values ranging from 6.20 to 22.74 mu M. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a c imigenol-skeleton can be proposed. (C) 2011 Elsevier Ltd. All rights reserved. |
| Keyword | Cimicifuga Foetida Ranunculaceae Cycloartane Triterpenoids Cytotoxicity Structure-activity Relationships |
| Subject Area | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytochem.2011.03.022 |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000293323800019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/5365 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China |
| Recommended Citation GB/T 7714 | Nian, Yin,Zhang, Xian-Min,Li, Yan,et al. Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus[J]. PHYTOCHEMISTRY,2011,72(11-12):1473-1481. |
| APA | Nian, Yin.,Zhang, Xian-Min.,Li, Yan.,Wang, Yuan-Yuan.,Chen, Jian-Chao.,...&Qiu, Ming-Hua.(2011).Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus.PHYTOCHEMISTRY,72(11-12),1473-1481. |
| MLA | Nian, Yin,et al."Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus".PHYTOCHEMISTRY 72.11-12(2011):1473-1481. |
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