Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus

doi:10.1016/j.phytochem.2011.03.022

	Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus
	Nian, Yin1,2 ; Zhang, Xian-Min 2; Li, Yan2 ; Wang, Yuan-Yuan 2; Chen, Jian-Chao 2; Lu, Lu 1,2; Zhou, Lin 2; Qiu, Ming-Hua1
通讯作者	Qiu, MH (reprint author), Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
	2011-08-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	72 期号:11-12 页码:1473-1481
摘要	Cycloartane triterpenoids, 2',24-O-diacetylisodahurinol-3-O-alpha-L-arabinopyranoside, 24-O-acetylisodahurinol-3-O-alpha-L-arabinopyranoside, 12 beta-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12 beta-hydroxy-15-deoxycimigenol, 2'-O-acetyl-24-epi-cimigenol-3-O-alpha-L-arabinopyranoside, 2'-O-acetylcimigenol-3-O-beta-D-xylopyranoside, 25-anhydrocimigenol-3-O-alpha-L-arabinopyranoside, 2',23-O-diacetylshenginanol-3-O-alpha-L-arabinopyranoside, and 2',24-O-diacetyl-25-anhydrohydroshengmanol-3-O-alpha-L-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC(50) values ranging from 6.20 to 22.74 mu M. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a c imigenol-skeleton can be proposed. (C) 2011 Elsevier Ltd. All rights reserved.
关键词	Cimicifuga Foetida Ranunculaceae Cycloartane Triterpenoids Cytotoxicity Structure-activity Relationships
学科领域	Biochemistry & Molecular Biology ; Plant Sciences
DOI	10.1016/j.phytochem.2011.03.022
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000293323800019
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/5365
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Zhang, Xian-Min,Li, Yan,et al. Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus[J]. PHYTOCHEMISTRY,2011,72(11-12):1473-1481.
APA	Nian, Yin.,Zhang, Xian-Min.,Li, Yan.,Wang, Yuan-Yuan.,Chen, Jian-Chao.,...&Qiu, Ming-Hua.(2011).Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus.PHYTOCHEMISTRY,72(11-12),1473-1481.
MLA	Nian, Yin,et al."Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus".PHYTOCHEMISTRY 72.11-12(2011):1473-1481.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
201203200020.pdf（368KB）			开放获取	--	浏览下载