Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus
Nian, Yin1,2; Zhang, Xian-Min2; Li, Yan2; Wang, Yuan-Yuan2; Chen, Jian-Chao2; Lu, Lu1,2; Zhou, Lin2; Qiu, Ming-Hua1
2011-08-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号72期号:11-12页码:1473-1481
摘要Cycloartane triterpenoids, 2',24-O-diacetylisodahurinol-3-O-alpha-L-arabinopyranoside, 24-O-acetylisodahurinol-3-O-alpha-L-arabinopyranoside, 12 beta-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12 beta-hydroxy-15-deoxycimigenol, 2'-O-acetyl-24-epi-cimigenol-3-O-alpha-L-arabinopyranoside, 2'-O-acetylcimigenol-3-O-beta-D-xylopyranoside, 25-anhydrocimigenol-3-O-alpha-L-arabinopyranoside, 2',23-O-diacetylshenginanol-3-O-alpha-L-arabinopyranoside, and 2',24-O-diacetyl-25-anhydrohydroshengmanol-3-O-alpha-L-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC(50) values ranging from 6.20 to 22.74 mu M. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a c imigenol-skeleton can be proposed. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Cimicifuga Foetida Ranunculaceae Cycloartane Triterpenoids Cytotoxicity Structure-activity Relationships
资助信息Foundation of the Key State Laboratory of Phytochemistry[P2008-ZZ05]; National Natural Science Foundation of China[30772636]; National Science Foundation of Yunnan Province[2005C0010Z]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2011.03.022
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000293323800019
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5365
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Nian, Yin,Zhang, Xian-Min,Li, Yan,et al. Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus[J]. PHYTOCHEMISTRY,2011,72(11-12):1473-1481.
APA Nian, Yin.,Zhang, Xian-Min.,Li, Yan.,Wang, Yuan-Yuan.,Chen, Jian-Chao.,...&Qiu, Ming-Hua.(2011).Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus.PHYTOCHEMISTRY,72(11-12),1473-1481.
MLA Nian, Yin,et al."Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus".PHYTOCHEMISTRY 72.11-12(2011):1473-1481.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
201203200020.pdf(368KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Nian, Yin]的文章
[Zhang, Xian-Min]的文章
[Li, Yan]的文章
百度学术
百度学术中相似的文章
[Nian, Yin]的文章
[Zhang, Xian-Min]的文章
[Li, Yan]的文章
必应学术
必应学术中相似的文章
[Nian, Yin]的文章
[Zhang, Xian-Min]的文章
[Li, Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。