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题名: Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus
作者: Nian, Yin1, 2; Zhang, Xian-Min2; null(李艳)2; Wang, Yuan-Yuan2; Chen, Jian-Chao2; Lu, Lu1, 2; Zhou, Lin2; null(邱明华)1
刊名: PHYTOCHEMISTRY
关键词: Cimicifuga foetida ; Ranunculaceae ; Cycloartane triterpenoids ; Cytotoxicity ; Structure-activity relationships
英文摘要: Cycloartane triterpenoids, 2',24-O-diacetylisodahurinol-3-O-alpha-L-arabinopyranoside, 24-O-acetylisodahurinol-3-O-alpha-L-arabinopyranoside, 12 beta-hydroxy-25-anhydrocimigenol, cimigenol-12-one, 12 beta-hydroxy-15-deoxycimigenol, 2'-O-acetyl-24-epi-cimigenol-3-O-alpha-L-arabinopyranoside, 2'-O-acetylcimigenol-3-O-beta-D-xylopyranoside, 25-anhydrocimigenol-3-O-alpha-L-arabinopyranoside, 2',23-O-diacetylshenginanol-3-O-alpha-L-arabinopyranoside, and 2',24-O-diacetyl-25-anhydrohydroshengmanol-3-O-alpha-L-arabinopyranoside, together with eight known compounds, were isolated from aerial parts of Cimicifuga foetida. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines indicated that three of these compounds exhibited broad-spectrum and moderate cytotoxic activities, with IC(50) values ranging from 6.20 to 22.74 mu M. By comparing previous cytotoxic testing data and bioassay results from this study, preliminary structure-activity relationships of compounds with a c imigenol-skeleton can be proposed. (C) 2011 Elsevier Ltd. All rights reserved.
出版日期: 2011-08-01
卷号: 72, 期号:11-12, 页码:1473-1481
DOI标识: 10.1016/j.phytochem.2011.03.022
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology; Plant Sciences
ISSN号: 0031-9422
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5365
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Nian, Y; Zhang, XM; Li, Y; Wang, YY; Chen, JC; Lu, L; Zhou, L; Qiu, MH.Cycloartane triterpenoids from the aerial parts of Cimicifuga foetida Linnaeus,PHYTOCHEMISTRY,2011,72(11-12):1473-1481
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