中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: The protective role of 5-HMF against hypoxic injury
作者: Li, Ming-Ming1, 2; Wu, Li-Ying1; Zhao, Tong1; Xiong, Lei1; Huang, Xin1; Liu, Zhao-Hui1; Fan, Xue-Lai1; Xiao, Cheng-Rong3; Gao, Yue3; Ma, Yun-Bao4; null(陈纪军)4; Zhu, Ling-Ling1; Fan, Ming1, 2
刊名: CELL STRESS & CHAPERONES
关键词: 5-HMF ; Hypoxic injury ; ECV304 cells ; MMP
英文摘要: In an attempt to find new types of anti-hypoxic agents from herbs, we identified 5-hydroxymethyl-2-furfural (5-HMF) as a natural agent that fulfills the criterion. 5-HMF, the final product of carbohydrate metabolism, has favorable biological effects such as anti-oxidant activity and inhibiting sickling of red blood cells. The role of 5-HMF in hypoxia, however, is not yet. Our pilot results showed that pretreatment with 5-HMF markedly increased both the survival time and the survival rate of mice under hypoxic stress. The present study was aimed to further investigate the protective role of 5-HMF and the underlying mechanisms in hypoxic injury using ECV304 cells as an in vitro model. ECV304 cells pretreated with or without 5-HMF for 1 h were exposed to hypoxic condition (0.3% O-2) for 24 h and then cell apoptosis, necrosis, the changes of mitochondrial membrane potential (MMP) and the expressions of phosphorylation- extracellular signal-regulated kinase (p-ERK) were investigated. Pretreatment with 5-HMF markedly attenuated hypoxia-induced cell necrosis and apoptosis at late stage (p < 0.01). Furthermore, pretreatment with 5-HMF rescued both the decline of the MMP and the increase of p-ERK protein under hypoxia. In a word, these results indicated that 5-HMF had protective effects against hypoxic injury in ECV304 cells, and its effects on MMP and p-ERK may be involved in the mechanism.
出版日期: 2011-05-01
卷号: 16, 期号:3, 页码:267-273
DOI标识: 10.1007/s12192-010-0238-2
语种: 英语
收录类别: SCI
学科分类: Cell Biology
ISSN号: 1355-8145
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/5335
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
201204050007.pdf(241KB)----开放获取--View Download

作者单位: 1.Inst Basic Med Sci, Dept Brain Protect & Plast, Beijing 100850, Peoples R China
2.Capital Med Univ, Sch Basic Med Sci, Beijing Inst Neurosci, Beijing 100069, Peoples R China
3.Beijing Inst Radiat Med, Beijing 100850, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources Western, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Li, MM; Wu, LY; Zhao, T; Xiong, L; Huang, X; Liu, ZH; Fan, XL; Xiao, CR; Gao, Y; Ma, YB; Chen, JJ; Zhu, LL; Fan, M.The protective role of 5-HMF against hypoxic injury,CELL STRESS & CHAPERONES,2011,16(3):267-273
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Ming-Ming]'s Articles
[Wu, Li-Ying]'s Articles
[Zhao, Tong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Ming-Ming]‘s Articles
[Wu, Li-Ying]‘s Articles
[Zhao, Tong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 201204050007.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace