| Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis | |
Geng, Chang-An1,2 ; Wang, Li-Jun1,2; Zhang, Xue-Mei1; Ma, Yun-Bao1; Huang, Xiao-Yan1; Luo, Jie1; Guo, Rui-Hua1,2; Zhou, Jun1; Shen, Yong1; Zuo, Ai-Xue1; Jiang, Zhi-Yong1; Chen, Ji-Jun1
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| 通讯作者 | Chen, JJ (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China |
| 2011-03-01 | |
| 发表期刊 | CHEMISTRY-A EUROPEAN JOURNAL
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| ISSN | 0947-6539 |
| 卷号 | 17期号:14页码:3893-3903 |
| 摘要 | Swerilactones H-K (1-4), which are four novel lactones with an unprecedented C29 skeleton, were isolated from Swertia mileensis (Qing-Ye-Dan), an endemic Chinese herb used for treating viral hepatitis. Their structures were determined by extensive spectroscopic and X-ray crystallographic diffraction analyses. Swerilactones H-K exhibit potent anti-hepatitis B virus activity against HBV DNA replication with IC(50) values ranging from 1.53 to 5.34 mu m. For the first time, a plausible biogenetic pathway for swerilactones H-K, together with the previously reported swerilactones A-D is proposed. From a biogenetic point of view, swerilactones A-D are ascribed as secoiridoid dimers, and swerilactones H-K as secoiridoid trimers. |
| 关键词 | Antiviral Agents Biosynthesis Fused-ring Systems Hepatitis b Virus Natural Products Swerilactones H-k Swertia Mileensis |
| 学科领域 | Chemistry |
| DOI | 10.1002/chem.201003180 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000288566700013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/5333 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Graduated Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Geng, Chang-An,Wang, Li-Jun,Zhang, Xue-Mei,et al. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(14):3893-3903. |
| APA | Geng, Chang-An.,Wang, Li-Jun.,Zhang, Xue-Mei.,Ma, Yun-Bao.,Huang, Xiao-Yan.,...&Chen, Ji-Jun.(2011).Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis.CHEMISTRY-A EUROPEAN JOURNAL,17(14),3893-3903. |
| MLA | Geng, Chang-An,et al."Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis".CHEMISTRY-A EUROPEAN JOURNAL 17.14(2011):3893-3903. |
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