Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis
Geng, Chang-An1,2; Wang, Li-Jun1,2; Zhang, Xue-Mei1; Ma, Yun-Bao1; Huang, Xiao-Yan1; Luo, Jie1; Guo, Rui-Hua1,2; Zhou, Jun1; Shen, Yong1; Zuo, Ai-Xue1; Jiang, Zhi-Yong1; Chen, Ji-Jun1
2011-03-01
发表期刊CHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
卷号17期号:14页码:3893-3903
摘要Swerilactones H-K (1-4), which are four novel lactones with an unprecedented C29 skeleton, were isolated from Swertia mileensis (Qing-Ye-Dan), an endemic Chinese herb used for treating viral hepatitis. Their structures were determined by extensive spectroscopic and X-ray crystallographic diffraction analyses. Swerilactones H-K exhibit potent anti-hepatitis B virus activity against HBV DNA replication with IC(50) values ranging from 1.53 to 5.34 mu m. For the first time, a plausible biogenetic pathway for swerilactones H-K, together with the previously reported swerilactones A-D is proposed. From a biogenetic point of view, swerilactones A-D are ascribed as secoiridoid dimers, and swerilactones H-K as secoiridoid trimers.
关键词Antiviral Agents Biosynthesis Fused-ring Systems Hepatitis b Virus Natural Products Swerilactones H-k Swertia Mileensis
资助信息National Natural Science Foundation of China and Yunnan Province[U0832603]; National Science Foundation of China[81025023]; Major Project of Innovative Engineering[KSCX2-YW-R-181]; Chinese Academy of Sciences; Freedom Project State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-ZZ08]
学科领域Chemistry
DOI10.1002/chem.201003180
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000288566700013
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5333
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Graduated Sch, Beijing 100039, Peoples R China
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Geng, Chang-An,Wang, Li-Jun,Zhang, Xue-Mei,et al. Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(14):3893-3903.
APA Geng, Chang-An.,Wang, Li-Jun.,Zhang, Xue-Mei.,Ma, Yun-Bao.,Huang, Xiao-Yan.,...&Chen, Ji-Jun.(2011).Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis.CHEMISTRY-A EUROPEAN JOURNAL,17(14),3893-3903.
MLA Geng, Chang-An,et al."Anti-Hepatitis B Virus Active Lactones from the Traditional Chinese Herb: Swertia mileensis".CHEMISTRY-A EUROPEAN JOURNAL 17.14(2011):3893-3903.
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