Overlapping chemical and genetic diversity in Ligularia lamarum and Ligularia subspicata. Isolation of ten new eremophilanes and a new seco-bakkane compound
Root chemicals and DNA sequences were analyzed for Ligularia lamarum samples collected in Yunnan and Sichuan Provinces of China and the relationship between the plant and Ligularia subspicata, its taxonomically closest species, was examined. Both species produce furanoeremophilanes and eremophilan-8-one derivatives as the major components. Eleven new compounds, including a new seco-bakkane compound, were isolated. The two species were found to harbor overlapping intra-specific diversities with respect to the chemicals and the DNA sequences. (C) 2011 Elsevier Ltd. All rights reserved.
1.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan 2.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan 3.Rikkyo Univ, Dept Life Sci, Toshima Ku, Tokyo 1718501, Japan 4.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan 5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation:
Saito, Y; Hattori, M; Iwamoto, Y; Takashima, Y; Mihara, K; Sasaki, Y; Fujiwara, M; Sakaoku, M; Shimizu, A; Chao, X; Kuroda, C; Gong, X; Hanai, R; Tori, M.Overlapping chemical and genetic diversity in Ligularia lamarum and Ligularia subspicata. Isolation of ten new eremophilanes and a new seco-bakkane compound,TETRAHEDRON,2011,67(12):2220-2231
