Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata
Xiao, Xiao1,2; Liu, Xi-Kui2; Fu, Shao-Bin1; Sun, Di-An1
2011
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号13期号:3页码:270-275
摘要Microbial transformation of diosgenin (1) by suspended-cell cultures of the filamentous fungus Cunninghamella echinulata CGMCC 3.2000 was investigated. Incubation of the substrate diosgenin (1) with this fungus led to the isolation of three products: two known compounds, (25R)-spirost-5-en-3,7,12-triol (2) and (25R)-spirost-5-en-3,7,11-triol (3), and a new compound (25R)-spirost-5-en-3,7,11-triol (4). The structural elucidations of the three compounds were achieved mainly by the MS, 1D and 2D NMR spectroscopic methods and comparison with known compounds. C. echinulata CGMCC 3.2000 has not been used before in the biotransformation of diosgenin (1).
关键词Microbial Transformation Biotransformation Hydroxylation Diosgenin Cunninghamella Echinulata Cgmcc 3 2000
资助信息New Drug Development Project of China[2009ZX09301-003]
学科领域Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
DOI10.1080/10286020.2010.551117
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000288674400013
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5233
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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Xiao, Xiao,Liu, Xi-Kui,Fu, Shao-Bin,et al. Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2011,13(3):270-275.
APA Xiao, Xiao,Liu, Xi-Kui,Fu, Shao-Bin,&Sun, Di-An.(2011).Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,13(3),270-275.
MLA Xiao, Xiao,et al."Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 13.3(2011):270-275.
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