Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii
Wang, Hong-Sheng2,3; Sun, Ling4; Wang, Yue-Hu2; Shi, Ya-Na2; Tang, Gui-Hua2; Zhao, Fu-Wei2; Niu, Hong-Mei2; Long, Chun-Lin1,2; Li, Ling4
2011-08-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号34期号:8页码:1283-1288
摘要A new dihydroflavone, 5-carboxymethyl-7,4'-dihydroxyflavonone (1), and its glucoside 5carboxymethyl-7,4'-dihydroxyflavonone-7-O-beta-D-glucopyranoside (2), and one new monoterpene glucoside, (4Z,6E)-2,7-dimethyl-8-hydroxyocta-4,6-dienoic acid 8-O-beta-D-glucopyranoside (3), were isolated from the whole plants of Selaginella moellendorffii. Their structures were determined by spectroscopic methods and chemical transformation. Compound 2 was evaluated for the ability to enhance glucose consumption in normal and insulin-resistant L6 muscle cells induced by high concentrations of insulin and glucose. Glucose consumption in insulin-resistant cells (but not in normal cells) was increased 15.2 +/- 3.3% (p < 0.01) by compound 2 at a concentration of 0.1 mu M in the presence of insulin (1 nM).
关键词Selaginellaceae Selaginella Moellendorffii Flavonoids Monoterpene Glucoside Insulin-resistance
资助信息National Natural Science Foundation of China[31070288, 20972166]; Ministry of Education of China[B08044, MUC 985]; Chinese Academy of Sciences; Yunnan Provincial Science Foundation[2006C009Z]
学科领域Pharmacology & Pharmacy
DOI10.1007/s12272-011-0807-7
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000294789700009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/5217
专题资源植物与生物技术所级重点实验室
作者单位1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
3.Henan Inst Sci & Technol, Xinxiang 453003, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
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Wang, Hong-Sheng,Sun, Ling,Wang, Yue-Hu,et al. Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(8):1283-1288.
APA Wang, Hong-Sheng.,Sun, Ling.,Wang, Yue-Hu.,Shi, Ya-Na.,Tang, Gui-Hua.,...&Li, Ling.(2011).Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii.ARCHIVES OF PHARMACAL RESEARCH,34(8),1283-1288.
MLA Wang, Hong-Sheng,et al."Carboxymethyl Flavonoids and A Monoterpene Glucoside from Selaginella moellendorffii".ARCHIVES OF PHARMACAL RESEARCH 34.8(2011):1283-1288.
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